direct oral anticoagulants Flashcards
1
Q
main indication
A
- Prevention of venous thrombosis in patients undergoing hip and knee replacements
- Used in treatment of DVT and PE
2
Q
mechanism of action
A
Newer agents which act as direct inhibitors of thrombin or factor Xa
Xa converts Prothrombin (II) to Thrombin (IIa)
3
Q
contraindications and cautions
A
No specific agent available to reduce haemorrhage in overdose BUT predictable degree of anticoagulation so minimal risk
4
Q
adverse effects
A
Bleeding
5
Q
administration
A
PO
