ACE inhibitors Flashcards
1
Q
examples of ACE inhibitors
A
ramipril
lisinopril
2
Q
main indications
A
- Hypertension - first line
- Heart failure
- Secondary prevention after MI
3
Q
mechanisms of action
A
- ACE inhibitors competitively inhibit the angiotensin converting enzyme (ACE), and thus reduce the generation of angiotensin-II, and also consequently aldosterone
- Thisreduces sodium and water retention
- Reduced tissue concentration of angiotensin-II also leads to arterial and venous dilation
4
Q
contraindications of cautions
A
- Afro-Caribbean’s do not respond well - CCBs first line instead
- May lower blood glucose in diabetics
- Contraindicated in pregnancy
- Be careful when used in combination with other drugs that can increase potassium
5
Q
adverse effects
A
- Persistent dry cough
- Renal dysfunction
- Angioedema
6
Q
administration
A
PO bedtime
