Fetal alcohol syndrome Flashcards
What is the incidence of FAS?
0.97/1000 live births
43/1000 live births among heavy drinkers
What is ARBD?
Alcohol-related birth defects
What is ARND?
Alcohol-related neurodevelopmental defects
What brain lesions are associated with alcohol exposure in utero?
- Microcephaly
- Cerebral dysgenesis
- Abnormal glial and neuronal migration
- Holoprosencephaly
- Agenesis or hypoplasia of the corpus callosum
- Absent olfactory lobes
- Hypoplasia of the hippocampus
- Abnormal or absent of basal ganglia
9, Hypoplastic or absent caudate nuclei
What is the threshold of alcohol intake where neurodevelopmental affects were noted?
> 15mL alcohol per day, more than 5 drinks per occasion on average at least once a week
What maternal factors affected cognitive deficits in a group of alcohol-exposed infants?
- Maternal age
2. Amount of alcohol consumed
What is the triad of features associated with FAS?
Must have documented exposure to alcohol in utero
- Pre and post-natal growth deficiency
- A characteristic pattern of facial abnormalities
- CNS dysfunction
What are the typical abnormal facial features associated with FAS?
- Short palpebral fissures
- Increased intercanthal distance
- Flattened face with short nose
- Absent or hypoplastic filtrum
- Bow shaped mouth with a thin upper lip
What are the infant diagnostic criteria associated with FAS?
History of prenatal alcohol exposure
Facial abnormalities
Growth retardation-height, weight, head circumference
Hypotonia, increased irritability
Jitteriness, tremulousness, weak suck
Difficulty ‘habituating’, getting used to stimulation
What are the preschool diagnostic criteria associated with FAS?
History of alcohol exposure, growth retardation, facial abnormalities
Friendly, talkative and alert
Temper tantrums and difficulty making transitions
Hyperactive; may be oversensitive to touch or over-stimulation
Apparent skill levels may appear to be higher than their tested levels of ability
Attention deficits, developmental delays-speech, fine motor difficulties
What are the middle childhood diagnostic criteria associated with FAS?
History of alcohol exposure, growth retardation, facial abnormalities
Hyperactivity, attention deficit, impulsiveness
Poor abstract thinking
Inability to foresee consequences of actions
Lack of organization and sequencing
Inability to make choices
Lack of organization skills
Inappropriate behaviour:
- Overly affectionate
- Lack of inhibitions
- Communication problems
- Lack of social skills to make and keep friends
- Unresponsive to social clues
- Uses behaviour as communication
- Difficulty making transitions
Academic problems-reading and mathematics
Behaviour problems-‘stretched toddler’
What are the adolescent and adult diagnostic criteria associated with FAS?
History of alcohol exposure, growth retardation, facial abnormalities
Intelligence Quotient-average to mildly retarded with wide range; continued school difficulties
Difficulty with adaptive and living skills
Attention deficits, poor judgment, impulsivity lead to problems with employment, stable living and the law
Serious life adjustment problems-depression, alcoholism, crime, pregnancy and suicide
What is the management approach to FAS?
- Change drinking attitudes in school-aged youth
- Identify at-risk drinkers
- Identify at-risk infants
- Early intervention to prevent secondary problems
- Develop a more precise and definitive diagnosis
Who is an abstainer?
Consume no alcohol
Who is a low-risk drinker?
Consume one to two standard drinks per day, three times a week or less. Alcohol has no effect on their health. They do not use alcohol while driving, while pregnant, when breastfeeding or with certain medications.