Female Reproductive Tract

Question 1

In the male Sertoli cells respond to FSH, which cell in the female respond to FSH?

Answer 1

Granulosa Cells

Question 2

In the male Leydig cells respond to LH, which cells in the female respond to LH?

Answer 2

Thecal Cells

Question 3

What is the difference between leydig cells and thecal cells?

Answer 3

Thecal cells do not express 17 Beta HSD(III)

Question 4

Which stage is important for the expression of glycoproteins ZP-1, ZP-2 and ZP-3?

Answer 4

Pre-Antral Stage of the Follicle

Question 5

Development of the Antral Follicle is dependent upon which glycoprotein released from what strucuture?

Answer 5

Antral Follicle is dependent upon FSH released from the Anterior Pituitary

Question 6

When is the first polar body produced?

Answer 6

After the LH surge during the large antral follicle

Question 7

Thecal cells produce which hormone to be exported to Granulosa Cells?

Answer 7

Androstenedione (A4)

Question 8

Function of FSH signalling to Granulosa cells?

Answer 8

FSH causes Granulosa cells to increase production of CYP19
FSH causes Granulosa cells to produce LH-Receptor
FSH induces Mural Granulosa cells to produce Inhibin-B (inhibits FSH production at AP)

Question 9

Role of FSH-R

Answer 9

Increases CYP19
Increases 17 Beta HSD
Increases Cell Proliferation
Causes expression of LH-R on granulosa cells

Question 10

Why does estrogen production decreases during LH surge?

Answer 10

LH surge promotes degredation of CYP19 and therefore estrogen cannot be synthesized

Question 11

Though little is known about the process? What causes positive feedback between secretion Estrogen and LH?

Answer 11

Selection of dominant follicle

Question 12

Cervical Muscus is thinnest during which stage of cycle?

Answer 12

Mid-cycle to allow sperm through

Question 13

What is the function of the isthmus in fertilization?

Answer 13

Extends life span of the sperm (~5 days)
Prevents premature capacitation
Hyperactivates the sperm