Adrenal Cortex Flashcards
Where is aldosterone made?
The Adrenal Cortex
Zona Granulosa
Where is Cortisol made?
The Adrenal Cortex
Zona Fasiculata
Where is DHEA made?
The Adrenal Cortex
Zona Retiuclaris
Where and by what cells is Norapinephrine/Epinephrine made?
The Adrenal Medulla via Chromaffin Cells
What causes chromaffin cells to produce catecholamines?
Influence of hypothalamus producing cortisol (via CRH pathway)
Directly via stimulating by ACh
During Hypoglycemia, catecholamines increase expression of which receptors that have what effects?
Increase alpha2-AR = Decrease Insulin Secretion
Increase beta2-AR = Increase Glucagon Secretion
Cortisol effects on liver?
Increase Glycogenolysis
Increase Gluconeogenesis
Cortisol effects on skeletal muscle?
- Increase adrenergic receptors
- Increase protein degradation
- Decrease Glut4
Cortisol effect on adipocyte?
- Increase AR
- Increaes lipolysis
- Decrease GLUT4
Major Reason for DHEA production in Zona Reticularis?
Zona Reticularis Lacks 3(Beta)-HSD
Enzyme that converts DHEA to DHEA-S?
SULT2A1
What product feedbacks to inhibit Hypothalamus production at the level of the adrenal gland?
Cortisol
Androgens do no negatively feedback
Without which major enzyme, is Cholesterol transformed into corticosterone?
CYP17
Unable to generate 17(OH)P4 without CYP14
Which protein made in the zona fasiculata is important for the production of aldosterone? What is the major enzyme specific to the zona glomerulus?
DOC
Deoxy Corticosterone
Major Enzyme: CYP11B2
