Digestion and Absorption of Lipids

Question 1

When is lingual/gastric lipase the major source of lipid metabolism?

Answer 1

Neonates

Question 2

Where does lipid digestion and metabolism take place

Answer 2

duodenum and jejunum

Question 3

Which peptide is critical for elevating the pH to 6.5 for optimal fat digestion?

Answer 3

Secretin

Question 4

Which protein can attach to the tri-glyceride allowing for the activity of lipase

Answer 4

Colipase (secreted as procolipase which is cleaved by typsin)

Question 5

Difference between short/medium fatty acids and chylomicrons?

Answer 5

short/medium fatty acids can be absorbed directly and enter the portal system, chylomicrons enter the lymphatic system

Question 6

Long Chain Fatty Acids induce the release of which peptides?

Answer 6

GIP, Secretin, CCK and GLP-1

Question 7

Long Chain Fatty Acids induce secretion of which products?

Answer 7

Bile Salts

Trypsinogen, Pancreatic Lipase, Choesterol Esterasae, Prohospholipase A2

Question 8

Difference between conjugated and non-conjugated acids

Answer 8

Conjugated bile acids require a lower [ ] of bile salts to form stable micelle.

Question 9

Which channel on enterocytes transports cholesterol into the cell?

Answer 9

NPC1L1

Question 10

ApoA1 is important marker of?

Answer 10

Nascent HDL

Question 11

Reasons for Fat in the Stool?

Answer 11

Low Bile
Poor absorption via enterocytes
Pancreatic deficiency
Bacterial Overgrowth

Question 12

Fat Soluble Vitamins

Answer 12

D, A, K, E