FeLV/FIV/FIP

Question 1

feLV virus type

Answer 1

gamma retrovirus

Question 2

transmission of felv?

Answer 2

saliva, social behaviour
kittens, new cats in home

Question 3

describe felv infection

Answer 3

after exposure-> abortive (healthy), 40%, or transient viremia 6-8wks. viremia lasts 3-13wks-> healthy carrier or progressive infection (30%) or regressive infection 10-30% (gets eliminated). regressive can become progressive w stress

Question 4

which infection have feLV disease?

Answer 4

progressive, not regressive

Question 5

C/s of feLV

Answer 5

weight loss, fever, conjunctivitis, rhinitis

Question 6

CBC of feLV

Answer 6

anemia- non regenerative after BM suppression
penias, platelet abnormalities

Question 7

immune mediated conditions from feLV

Answer 7

IMHA, ITP, IMPA, uveitis, glomerulonephritis

Question 8

neoplasia w feLV?

Answer 8

lymphoma mostly, leukemias

Question 9

who should be tested for feLV/FIV

Answer 9

any sick cat, before adoption, outdoor urban cats, unknown feLV, cats living w a +ve cat

Question 10

types of tests for felV

Answer 10

ELISA Ag test- screening test, can have false +ve-> tests p27 Ag
IFA- confirmatory test
PCR- confirmatory, can catch -ve p27 Ag (ELISA -ve)

Question 11

feLV ELISA

Answer 11

measures p27, positive within 30d-> retest +ves, <12wks, <30d exposure

Question 12

feLV IFA

Answer 12

detects p27 from BM after virus replication-> more specific *not screening test

Question 13

testing for different feLV infection types

Answer 13

transient, viremia- +ve ELISA, PCR
progressive, carrier- all +ve (IFA)
regressive- +ve PCR, -ve ELISA and IFA

Question 14

tx for feLV cats

Answer 14

healthy- indoors, vx, give perioperative abx
sick- blood transfusion, erythropoietin, filgrastim, chemo

zidovudine antiviral

Question 15

feLV vx

Answer 15

test before vx
free roaming urban cats
vx will not cause +ve test

Question 16

survival feLV

Answer 16

viremic cats:
50% in 2y, 80% 3y

Question 17

FIV virus

Answer 17

lentivirus, 5 subtypes
transmission through bite,fight wounds

Question 18

describe FIV infection

Answer 18

infects B/T cells, macrophages-> dissemination to lymphoid organs,-> decreased cd4 cells-> decreased immunity

leads to progressive immune dysfunction-> can show CNS signs

C/S will decrease with host response

Question 19

FIV C/S

Answer 19

fever, lymphadenopathy, stomatitis, neuro signs

Question 20

FIV dx

Answer 20

CBC- penias
chem- azotemia (CKD), hyperglobulinemia

SNAP ELISA, western blot, IFA (Ab), PCR

Question 21

FIV testing

Answer 21

retest +ves <6m, confirm ELISA w western blot or PCR-> if -ve retest in 60d

Question 22

does FIV increase risk of neoplasia?

Answer 22

yes, but not as much as feLV, usually lymphoma

Question 23

FIV tx

Answer 23

AZT antiviral, dental extractions, human interferon alpha

keep indoors, vx, isolation

Question 24

FIP pathogenesis

Answer 24

mutated feline coronavirus (fecal-oral)-> moves from gut to macrophages

wet- vasculitis, effusion
dry- granulomatous lesions (immune complexes)

Question 25

FIP C/S

Answer 25

fever, uveitis, abd distension, dyspnea

young cats 3m-3y, or old >13y,

Question 26

FIP dx

Answer 26

CBC- lymphopenia, NR anemia, thrimbocytopenia
chem- hyperglobulinemia, high TP, ALB:GLOB <0.8

rads- effusion
rivlatas test-drop disappears= -ve

Question 27

FIP fluid analysis

Answer 27

effusion- high TP >3.5, low cells, (transudate)
pyogranulomatous effusion-> viscous, macrophages and neutrophils
RTPCR on abd effusion

Question 28

FIP tx

Answer 28

remdesivir, GS-441524 oral