Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

.infection & immunity > Feline diseases > Flashcards

Feline diseases Flashcards

1
Q

Parvoviridae characteristics

A

Can cause disease in felids, raccoon, minks (DNA)
CP strains can cause FPV
Most common in kittens infected @ weaning

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Parvoviridae in felines causes ___________

A

Feline panleukemia virus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Transmission of Feline panleukemia

A

Direct contact with infected cats or fomites
Fleas and humans mechanical vectors
Sheds in feces, urine, saliva and vomitus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

CS of Feline panleukemia

A

Profound leukopenia direct cause of sudden death (peracute)
Lymphopenia + neutropenia
Fever (24hrs +)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Acute stage of Feline panleukemia

A

High temp on the 3rd or 4th day
Rough coat, loss of appetite, vomit
Frequently bloody diarrhea
Death due to dehydration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Perinatal/ in utero infection of kittens with Feline panleukemia

A

Abnormal development of the cerebellum
Ataxic
@ 3 wks = spastic/ Wobbly cat syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Pathogenesis of Feline panleukemia (resp.)

A

Virus enters the oropharynx (viral replication) → disseminates in blood → S phase cells targeted and killed

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Pathogenesis of Feline panleukemia (GI)

A

Intestinal crypts infected and destroyed → ulceration, malabsorption and diarrhea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Pathogenesis of Feline panleukemia (in-utero infection)

A

Hypoplasia/ atrophy in the external granular layer of the cerebellum in fetuses during the last 2 wks of pregnancy and first 2 weeks of life

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Dx of Feline panleukemia

A

CS, hematological data and post mortem findings sufficient
Others: ELISA, IF i tissues, PCR, IDEXX Snap parvo test

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Immunity and control of Feline panleukemia

A

Inactivated and live modified virus vx @ > 4 wks old
Hygiene and disinfectants
Infected animals quarantined for 14 days

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Retroviridae (Feline Immunodeficiency virus) characteristics

A

Domesticated cats worldwide
Significant cause of immune suppression in old infected cats

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

3 stages of FIV

A

Acute: lymphadenopathy, fever, leukemia
Sub-clinical: active immune response
Terminal: progressive loss of immune function, opportunistic infections and neoplasia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

CS in the terminal stages of FIV

A

Opportunistic bacterials and fungal infections in the mouth (stomatitis), periodontal tissue, cheeks and tongue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Transmission of FIV

A

Bite wounds
Shed in saliva

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

In what stage can FIV be detected in the blood

A

Acute stage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

FIV in the blood

A

Suppression of circulating viral load
↑ CD8+ and CD4+ T cells → then decline and cat susceptible to infection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Dx of FIV

A

SNAP test: Abs to p24 capsid protein (can’t diff between vx and non vx infected cats)
Virus culture *** (gold standard)
PCR with serological assays

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Confirmatory dx of FIV

A

Cats @ low risk and asymptomatic but exposed or + by SNAP and unvx
Use Western blot and IF assays

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Do kittens get infected with FIV?

A

Not really if < 6 months old due to maternal Abs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Retroviridae (Feline leukemia and sarcoma) taxonomy

A

Subfamily: Orthoretovirinae
Genus: Gammaretrovirus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Feline leukemia and sarcoma (FeLV)

A

Enzootic in domestic cats and other felids
Lifelong, incurable infectious disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Risk factors of FeLV

A

Free access to outdoors
Age ( young < 6 months)
Male gender

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

FeLV transmission

A

Grooming, transplacental/ nursing, bit wounds and fleas
Contact wit saliva, urine and feces

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Pathogenesis of FeLV
Oropharyngeal →replication in lymphoid tissues → spread to BM via monos, lymphos, mucosal and glandular epithelial cells
26
3 types of neoplasia caused by FeLV
Lymphosarcoma** Myeloproliferative disease Fibrosarcoma
27
CS of FeLV
Anemia, immunodeficiency and bacterial infection
28
Lesions associated with FeLV
Firm homogenous pale tissue of neoplastic lymphocytes (white raised lesions)
29
Ags of FeLV
High level in blood Produced during infection from immune complexes of Ab-Ag that gets deposited in capillaries in kidney → glomerulonephritis
30
Transient Viremia (latent stage) of FeLV
Detected in first few weeks to months Cats control infection by good level of Abs Absent in blood Provirus in blood, absent in tissue → not infective Reactivated if cat immunosuppressed
31
Progression infection of FeLV
Cant control infection/ virus Develop lymphomas and secondary bacterial infection Shed virus → source of infection
32
Dx of FeLV
SNAP: p27 Ag in blood within 1 mon of exposure: repeated every 1-3 m PCR (presence of provirus) IFA with WBC/BM
33
Vx for FeLV
Whole inactivated vx with varied efficacy Subunit vx most effective Recc for - cats only
34
Lymphocyte T-cell Immunomodulator (LTCI)
First USDA approved treatment aid for cats with FeLV and FIV ↑ CD4 lympho function and #s and ↑ IL-2 production
35
Which species does feline caliciviridae affect?
Infects many species (birds, marine mammals, rodents, cats, dogs, etc) Affects any age of cats but kittens more severe
36
Feline Caliciviridae
Genetically heretogenous (RNA) Genus: vesivirus
37
Mild infection of feline caliciviridae
Affects oral epithelium (oral ulceration) , resp. infection and pneumonias
38
High virulent systemic strains of feline caliciviridae
SQ facial and limb edema, icterus, alopecia Striking ulceration of nose, pinnae, feet
39
Feline caliciviridae transmission
Fomites Direct contact between cats Aerosol Shed oral secretions for extended periods
40
Dx of feline caliciviridae
Isolation of virus in feline cell culture Viral Ag in infected tissue by IF, IHC, RT-PCR (healthy cats may test +) Serology
41
Vx for feline caliciviridae
Modified live virus vx and multi-strain vx (intra nasal)
42
Core vx for cats
FPV, FHV-1, FCV, Rabies
43
Decontamination of sources of infection (feline caliciviridae)
Sodium hypochlorite solution * if not used properly can cause lesions*
44
Felid Herpesvirus 1 (Feline viral rhinotracheitis)
Causes acute disease of the upper resp. tract (cats in their first year of life)- DNA Sub-clinical/ mild in cats > 6 months
45
CS of Felid Herpesvirus 1/ Feline viral rhinotracheitis
Resp. signs Pregnant queens may abort
46
Macroscopic lesions of Felid Herpesvirus 1
Ulcers on the tongue Keratitis with punctate corneal ulcers
47
Microscopic lesions of Felid Herpesvirus 1
Necrosis of epithelia of the nasal cavity, pharynx, epiglottis, tonsils, larynx and trachea IBs → death within 7-9 dys
48
________ is an important cause of corneal disease in cats
FHV-1
49
Which diseases does coronaviridae cause?
Feline enteric coronavirus Feline Infectious Peritonitis *Coronavirdiae is a DNA virus*
50
Feline enteric coronavirus (FECV)
Mutation leads to FIP Endemic in cats (90% catteries, 50% single) Involves multiple organs
51
Feline Infectious Peritonitis (FIP)
Progressive immune mediated debilitating lethal disease of felidae In young and very old (3m-3y) Abdominal effusion (wet type) and dry type
52
FIP CS for dry type
Anorexia, chronic fever, malaise, WL Ocular/ neurological signs might occur May progress to wet form
53
FIP CS of the wet form
Progressive abdominal distension → highly viscous fluid in the PC Death within weeks
54
Cats that develop the dry and wet forms of FIP
Foci of pyogranulamatous inflammation in several organs
55
FIP pathogenesis
Fecal-oral → infection of monos and macros → shields virus fro Abs and triggers inflamm cytokines
56
Lesions of FIP
Centered on small BVs Vascular injury due to Ab-AG complexes and leakage (wet form)
57
Gross pathology of FIP
Thick, Viscous, clear yellow peritoneal exudate (wet form) Fibrinous plaques with numerous discrete gray-white modules in omentum, liver, kidney, brain, uvea)
58
DX of FIP (antenortem)
Suggestive of FIV= Serum biochemical tests: hyperproteinemia due to hypergloinemia IF of CoAg in macros RT-PCR
59
Dx of FIP (postmortem)
Definitive dx: immunohistochemical staining for coronavirus Ag within lesions → pyogranulomatous or granulomatous vasculitis
60
Immunity and control of FIP
Temp- sensitive mutant vx for young cats → immune response to vx enhances infections Control: hygiene and separation of queen and kittens

.infection & immunity (12 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions