Face & Neck Pathology Flashcards
nuclear medicine utilizes ______ to classify thyroid nodules
scintigraphy
hyperfunctioning thyroid nodules or “hot nodules” appear as _____
dark areas
hypofunctioning thyroid nodules or “cold nodules” appear as _____
light or blank areas
most thyroid cancers are _____
hypofunctioning
“cold nodules”
_____ is the most effective method for diagnosing malignancy in a thyroid nodule
fine needle aspiration (FNA)
FNA should be considered in a (5)
- nodule > 1.0 cm with microcalcifications
- nodule > 1.5 cm that is predominately solid
- nodule > 2.0 cm that has mixed components
- nodule demonstrating growth
- nodule with ipsilateral abnormal lymph nodes ( > 7mm in short axis )
what does TI-RADS stand for?
thyroid imaging, reporting and data system
what is TI-RADS used for?
identifies most clinically significant malignancies while reducing the number of biopsies performed on benign nodules
TI-RADS categories (5)
benign
not suspicious
minimally suspicious
moderately suspicious
highly suspicious for malignancy
malignant features of thyroid nodules (5)
solid
hypoechoic
taller than wide
lobulated or irregular margins
calcifications
what is a goiter?
abnormal enlargement of the thyroid gland
what is the most common cause worldwide of goiters?
iodine deficiency
other causes of goiters (2)
hashimoto’s
grave’s
nontoxic/simple goiters are associated with
normal or low thyroid hormone levels
ultrasound appearance of nontoxic/simple goiters
homogenous, diffuse enlargement
toxic/multinodular goiters are associated with
hyperparathyroidism
ultrasound appearance of toxic/multinodular goiters
heterogeneous
decreased echogenicity
signs/symptoms of goiters (4)
dysphagia
dyspnea
coughing
hoarseness
another name for Grave’s disease
diffuse toxic goiter
what is the most common cause of hyperthyroidism?
grave’s disease
the presence of _____ is in grave’s disease
thyroid-stimulating immunoglobins
ultrasound appearance of Grave’s disease (2)
** thyroid inferno **
diffusely heterogeneous or hypoechoic
signs/symptoms of Grave’s (5)
bulging eyes
weight loss
tremors
tachycardia
heat intolerance
what is euthyroid?
thyroid is producing the right amount of thyroid hormones
5 types of thyroiditis
- hashimotos
- subacute granulomatous thyroiditis
- subacute lymphocytic thyroiditis
- acute suppurative thyroiditis
- riedel struma
another name for hashimotos
chronic lymphocytic thyroiditis
____ is the most common cause of hypothyroidism
hashimoto’s
lab values of hyperthyroidism
increase T3 and T4
decrease TSH
lab values of hypothyroidism
decrease T3 and T4
increase TSH
ultrasound appearance of Hashimoto’s (3)
- diffusely heterogeneous
- coarse parenchyma
- multiple, ill-defined hypoechoic regions separated by fibrous hyperechoic tissue
signs/symptoms of Hashimoto’s (5)
puffiness under eyes
puffy face
dry skin
increased cold sensitivity
elevated blood cholesterol levels
what is the most common mass identified within the thyroid?
benign nodule
___ is the most common type of thyroid adenoma
follicular adenoma
what is the most common cause of thyroid nodules?
nodular hyperplasia
adenomatous nodules are _____
hyperplastic nodules
____ nodules are cystic and have hyperechoic foci that produce ____ artifacts
colloid nodules
produce comet-tail artifacts
what is the most common primary thyroid cancer?
papillary carcinoma
____ carcinoma is the least aggressive of thyroid tumors
papillary carcinoma
papillary carcinoma spreads through the _____ to nearby _____
spreads through the lymphatics to nearby cervical lymph nodes
ultrasound appearance of papillary carcinoma (3)
hypoechoic
calcifications
hypervascular
what is the second most common thyroid cancer?
follicular carcinoma
follicular carcinoma spreads via ____ and metastasize to the ____
spreads via blood streams
metastasize to lungs and bone
ultrasound appearance of follicular carcinoma (3)
irregular margins
thick irregular halo
chaotic arrangement of internal blood vessels
medullary carcinoma develop from _____ that secrete calcitonin
parafollicular cells
medullary carcinoma is associated with ____
MEN syndrome
what is the rarest and fastest growing thyroid cancer?
anaplastic carcinoma
anaplastic carcinoma usually causes death by (2)
compression and asphyxiation
what is the most common cause of an enlarged parathyroid gland?
parathyroid adenoma
ultrasound appearance of parathyroid adenomas (2)
single lesion (80%)
oval, hypoechoic
what is the most common type of hyperparathyroidism?
primary hyperparathyroidism
lab values of primary hyperparathyroidism (2)
increase serum calcium and PTH
in primary hyperparathyroidism there is an adenoma in ____ parathyroid gland
one
secondary hyperparathyroidism occurs in patients with ____
chronic renal failure
____ parathyroid glands are enlarged in secondary hyperparathyroidism
all 4 parathyroid glands
what is the most common manifestation of MEN type I?
secondary hyperparathyroidism
lab values of secondary hyperparathyroidism (2)
increase serum phosphates
decrease serum calcium
parathyroid carcinoma is ____
rare
what is sjögren syndrome?
autoimmune disease that leads to the dysfunction of the salivary glands
ultrasound appearance of sjögren syndrome (4)
heterogeneous
hyperemic
diffuse hypoechoic regions
sialadenitis
what is sialadenitis?
inflammation of the salivary glands
signs/symptoms of sjögren syndrome
severe dryness of the eyes, nose, skin, and mouth
what is sialolithiasis?
salivary duct stones most commonly located within the submandibular gland
what is sialadenosis?
benign, painless enlargement of the parotid glands
what is pleomorphic adenoma?
most frequent benign tumor of the salivary glands commonly seen in the parotid glands
what is the most common malignancy of the salivary glands?
mucoepidermoid carcinoma
mucoepidermoid carcinoma starts in the ____ glands
parotid glands
what is the most common superficial midline neck mass?
thyroglossal duct cyst
thyroglossal duct cysts are associated with ____ and typically seen in ____
associated with upper respiratory infections
seen in adolescents
ultrasound appearance of thyroglossal duct cyst
< 3 cm
well defined
cystic
what is a branchial cleft cyst?
congenital cyst that arises on the lateral part of the neck
_____ is a remnant of embryonic development
branchial cleft cyst
ultrasound appearance of branchial cleft cysts (3)
unilateral
cystic or complex
low level internal echoes
another name for cystic hygromas
cystic lymphangiomas
what is cystic hygroma?
congenital lymphatic malformation
____% of cystic hygromas occur in the neck
75%
cystic hygromas are associated with (4)
turner syndrome
trisomy 21
klinefelter syndrome (XXY)
trisomy 18 and 13
3 vessels of the aortic arch that extend into the neck
innominate (brachiocephalic) artery
left common carotid artery
left subclavian artery
there is ___ innominate artery and ___ innominate veins
1 artery (right)
2 veins
position of the ICA
lateral and posterior
the ICA has a ___ resistance waveform
low resistance
1st branch of the ICA
ophthalmic artery
position of the ECA
medial and anterior
the ECA shows a ____ resistance waveform
high resistance
1st branch of the ECA
superior thyroid artery
what two veins drain into the innominate vein?
internal jugular and subclavian
what is fibromatosis colli?
rare, pediatric fibrous tumor within the sternocleidomastoid muscle
fibromatosis colli causes twisting off the infant’s chin toward the nonaffected side which is termed ____
congenital muscular torticollis
ultrasound appearance of fibromatosis colli (3)
fusiform-shaped mass
calcifications that shadow
hyperemic pattern with color doppler