FA Repro Pharm Flashcards
GnRH analog with agonist properties when used in pulsatile fashion; antagonistic properties when used in continuous fashion
Leuprolide
Antagonist at estrogen receptors in hypothalamus. Prevents normal feedback inhibition and increased release of LH and FSH from pituitary, which stimulates ovulation.
Clomiphene
Antagonist on breast tissue; agonist at uterus, bone;
Tamoxifen
Agonist on bone; antagonist at uterus
Raloxifene
Aromatose inhibitors used in postmenopausal women with breast cancer
Anastrozole/exemestane
Bind progesterone receptors, decrease growth and increase vascularization of endometrium
Progestins
Competitive inhibitor of progestins at progesterone receptors
Mifepristone (RU-486)
Beta2-agonist that realizes the uterus; used to decrease contraction frequency in women during labor
Terbutaline
Synthetic androgen that acts as partial agonist at androgen receptors
Danazol
Agonist at androgen receptors
Testosterone, methyltestosterone
5alpha-reducatase inhibitor (decreases conversion of testosterone to DHT).
Finasteride
A non-steroidal competitive inhibitor of androgens at the testosterone receptor. Used in prostate carcinoma.
Flutamide
Inhibits steroid synthesis (inhibits 17,20-desmolase)
Ketoconazole
Inhibits steroid binding, 17-alpha-hydroxylase, and 17,20-desmolase
Spironolactone
Alpha1-antagonist used to treat BPH by inhibiting smooth muscle contraction. Selective for alpha1A,D receptors (found on prostate) vs. vascular alpha1B receptors.
Tamsulosin
