Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Drugs > FA Immuno Pharm > Flashcards

FA Immuno Pharm Flashcards

1
Q

CU epoetin alfa (erythropoietin)

A

Anemias, esp in renal failure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

CU thrombopoietin

A

Thrombocytopenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

CU oprelvekin (IL-11)

A

Thrombocytopenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

CU filgrastim (G-CSF)

A

Recovery of bone marrow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

CU sargamostim (GM-CSF)

A

Recovery of bone marrow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

CU Aldesleukin (IL-2)

A

Renal cell carcinoma, metastatic melanoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

CU IFN-alpha

A 
Chronic hepatitis B and C,
Kaposi sarcoma,
Hairy cell leukemia, 
condyloma acuminatum,
renal cell carcinoma,
Malignant melanoma
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

CU IFN-beta

A

MS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

CU IFN-gamma

A

CGD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Alemtuzumab =

A

anti-CD52

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Bevacizumab =

A

anti-VEGF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Cetuximab =

A

anti-EGFR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Rituximab =

A

anti-CD20

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Trastuzumab =

A

anti-HER2/neu

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

CU alemtuzumab

A

CLL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

CU bevcizumab

A

colorectal cancer, RCC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

CU cetuximab

A

stage IV colorectal cancer, head and neck cancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

CU rituximab

A

B-cell non-Hodgkin lymphoma,
RA (with MTX),
ITP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

CU trastuzumab

A

Breast cancer, gastric cancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Infliximab =

A

anti-TNF-alpha

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Adalimumab =

A

anti-TNF-alpha

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

CU infliximab

A

IBD, RA, ankylosing spondylitis, psoriasis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

CU adalimumab

A

IBD, RA, ankylosing spondylitis, psoriasis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Natalizumab =

A

anti-alpha4-integrin

25
Q

alpha4-integrin is important for:

A

leukocyte adhesion

26
Q

CU natalizumab

A

MS, Crohn disease

27
Q

SE natalizumab

A

risk of PML in patients with JC virus

28
Q

Abciximab =

A

anti-glycoprotein IIb/IIIa

29
Q

CU abciximab

A

anti-platelet agent for prevention of ischemic complications in patients undergoing percutaneous coronary intervention

30
Q

Denosumab =

A

anti-RANKL

31
Q

CU denosumab

A

osteoporosis: inhibits osteoclast maturation (mimics osteoprotegrin)

32
Q

CU digoxin immune Fab

A

Antidote for digoxin toxicity

33
Q

Omalizumab =

A

anti-IgE

34
Q

CU omalizumab

A

allergic astma: prevents IgE binding to FCepsilonRI (add on therapy)

35
Q

Palivizumab =

A

anti-RSV F protein;

36
Q

CU palivizumab

A

RSV prophylaxis for his risk infants

37
Q

Calcineurin inhibitor; binds cyclophilin. Blocks T cell activation by preventing IL-2 transcription

A

Cyclosporine

38
Q

CU cyclosporine

A

transplant rejection prophylaxis, psoriasis, RA

39
Q

Tox cyclosporine

A
  • Nephrotoxicity,
  • HTN, hyperlipidemia, hyperglycemia,
  • Tremor
  • Hirsuitism, gingival hyperplasia
40
Q

Calcineurin inhibitor; binds FK506 binding protein (FKBP); blocks T cell activation by preventing IL-2 transcription

A

Tacrolimus

note that all -limus drugs bind FKBP!

41
Q

CU Tacrolimus

A

Transplant rejection prophylaxis

42
Q

Tox tacrolimus

A
  • Diabetes & neurotoxicity (more than cyclosporine)
  • Nephrotoxicity,
  • HTN, hyperlipidemia, hyperglycemia,
  • Tremor
43
Q

mTOR inhibitor; binds FKBP; blocks T cell activation and B cell differentiation by preventing IL-2 signal transduction

A

Sirolimus (rapamycin)

44
Q

CU sirolimus (rapamycin)

A

kidney transplant rejection prophylaxis

45
Q

Tox sirolimus (rapamycin)

A

anemia, thrombocytopenia, leukopenia, hyperlipidemia, but NOT nephrotoxic

46
Q

Basiliximab =

A

anti-IL-2R

47
Q

CU Basiliximab

A

kidney transplant prophylaxis

48
Q

Tox Basiliximab

A

Edema, HTN, tremor

49
Q

Antimetabolite precursor of 6-MP; inhibits lymphocyte proliferation by blocking nucleotide synthesis

A

Azathioprine

50
Q

CU azathioprine

A

transplant rejection prophylaxis;
RA; Crohns; glomerulonephritis;
other AI

51
Q

Tox azathioprine

A
  • leukopenia, anemia, thrombocytopenia

- NB: 6-MP is degraded by xanthine oxidase, so toxicity is increased by allopurinol

52
Q

Inhibit NF-kappaB; suppress B and T cell fxn by decreasing transcription of many cytokines

A

glucocorticoids

53
Q

CU glucocorticoids

A

transplant rejection prophylaxis, AI diseases, inflammation

54
Q

Tox glucocorticoids

A

hyperglycemia, osteoporosis, central obesity, muscle breakdown, psychosis, acne, HTN, cataracts, peptic ulcers

55
Q

MOA cyclosporine

A

Calcineurin inhibitor; binds cyclophilin. Blocks T cell activation by preventing IL-2 transcription

56
Q

MOA tacrolimus

A

Calcineurin inhibitor; binds FK506 binding protein (FKBP); blocks T cell activation by preventing IL-2 transcription

57
Q

MOA sirolimus (rapamycin)

A

mTOR inhibitor; binds FKBP; blocks T cell activation and B cell differentiation by preventing IL-2 signal transduction

58
Q

MOA azathioprine

A

Antimetabolite precursor of 6-MP; inhibits lymphocyte proliferation by blocking nucleotide synthesis

59
Q

MOA glucocorticoids

A

Inhibit NF-kappaB; suppress B and T cell fxn by decreasing transcription of many cytokines

Drugs (21 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions