FA GI Pharm Flashcards
Reversible block of histamine H2-receptors –> decreased H+ secretion by parietal cells
H2 blockers
Irreversibly inhibit H+/K+ ATPase in stomach parietal cells
Proton pump inhibitors
Bind to ulcer base, providing physical protection and allowing HCO3- secretion to reestablish pH gradient in the mucous layer
Bismuth, sucralfate
A PGE1 analog. Increased production and secretion of gastric mucous barrier, decreased acid production
Misoprostol
Long-acting somatostatin analog
Octreotide
Provide osmotic load to draw water out
Osmotic laxatives
treats hepatic encephalopathy since gut flora degrade it into metabolites (lactic acid and acetic acid) that promote nitrogen excretion as NH4+
Lactulose
Monoclonal antibody to TNF-alpha
Infliximab
A combination of sulfapyridine (antibacterial) and 5-aminosalicyclic acid (anti-inflammatory). Activated by colonic bacteria.
Sulfasalazine
5-HT3 antagonist; decreased vagal stimulation. Powerful central-acting antiemetic
Ondansetron
D2 receptor antagonist. Increased resting tone, contractility, LES tone, motility. Does not influence colonic transport time
Metoclopramide
CU: peptic ulcer, gastritis, mild esophageal reflux
H2 blockers
Ex: cimetidine, ranitidine, famotidine, nizatidine
H2 blockers
Ex: omeprazole, lanzoprazole, esmoeprazole, pantoprazole, dexlansoprazole
PPIs
CU: peptic ulcer, gastritis, esophageal reflux, ZES
PPIs