FA G-protein linked second messengers

Question 1

Vasoconstriction, pupil dilation, intestinal and bladder sphincter contraction

Answer 1

Alpha1 agonist (e.g., phenylephrine)

Question 2

Vasodilation, pupil constriction, intestinal and bladder sphincter relaxation

Answer 2

Alpha1 antagonist (e.g., tamsulosin)

Question 3

Decreased sympathetic outflow, insulin release, lipolysis, and aqueous humor production, increased platelet aggregation

Answer 3

Alpha2 agonist (e.g., clonidine, alpha-methyldopa, bromonidine)

Question 4

Increased sympathetic outflow, insulin release, and lipolysis; decreased platelet aggregation

Answer 4

Alpha2 antagonist (e.g., mirtazapine)

Question 5

Increased HR, contractility, renin, lipolysis

Answer 5

Beta1 agonist (e.g., dobutamine)

Question 6

Decreased HR, contractility, renin, lipolysis

Answer 6

Beta1 antagonist (e.g., metoprolol)

Question 7

• Vasodilation, bronchodilation
• increased HR, contractility, lipolysis, insulin release
• inc aqueous humor prod
• ciliary muscle relaxation
• decreased uterine tone (tocolysis)

Answer 7

Beta2 agonist (e.g., albuterol, terbutaline)

Question 8

• vaso & bronchoconstriction
• decreased HR, contractility, lipolysis, insulin release
• dec aqueous humor prod
• ciliary muscle contraction (accommodation)
• increased uterine tone

Answer 8

Beta2 antagonist

Question 9

CNS, enteric nervous system

Answer 9

M1

Question 10

decreased HR and contractility of atria

Answer 10

M2 agonist

Question 11

increased HR and contractility of atria

Answer 11

M2 antagonist (e.g., atropine)

Question 12

increased exocrine gland secretion, gut peristalsis, bladder contraction, bronchoconstriction, pupil constriction, ciliary muscle contraction (accommodation)

Answer 12

M3 agonist

Question 13

Cholinesterase inhibitor poisoning (i.e., nonselective muscarinic agonist)

Answer 13

DUMBBELS
Diarrhea 
Urination
Miosis
Bronchospasm
Bradycardia
Exc of skeletal musc. & CNS
Lacrimation
Sweating
Salivation

Question 14

Relaxes renal vascular smooth muscle

Answer 14

D1

Question 15

Modulates transmitter release, especially in the brain

Answer 15

D2

Question 16

Increased nasal and bronchial mucus production, increased vascular permeability, contraction of bronchioles, pruritus, pain

Answer 16

H1

Question 17

Increased gastric acid secretion

Answer 17

H2

Question 18

Increased vascular smooth muscle contraction

Answer 18

V1

Question 19

Increased H2O permeability and reabsorption in the CTs of the kidney

Answer 19

V2

Question 20

Atropine toxicity (ie. nonselective muscarinic antagonist)

Answer 20

Hot as a hare
Dry as a bone
Red as a beet
Blind as a bat
Mad as a hatter

Question 21

Which receptors use Gq –> PLC –> IP3 –> increased calcium? (and DAG –> PKC)

Answer 21

H1, alpha1, V1, M1, M3

Question 22

Which receptors use Gs –> increased cAMP?

Answer 22

Beta1, beta2, D1, H2, V2

Question 23

Which receptors use Gi –> decreased cAMP?

Answer 23

M2, alpha2, D2