FA G-protein linked second messengers Flashcards
Vasoconstriction, pupil dilation, intestinal and bladder sphincter contraction
Alpha1 agonist (e.g., phenylephrine)
Vasodilation, pupil constriction, intestinal and bladder sphincter relaxation
Alpha1 antagonist (e.g., tamsulosin)
Decreased sympathetic outflow, insulin release, lipolysis, and aqueous humor production, increased platelet aggregation
Alpha2 agonist (e.g., clonidine, alpha-methyldopa, bromonidine)
Increased sympathetic outflow, insulin release, and lipolysis; decreased platelet aggregation
Alpha2 antagonist (e.g., mirtazapine)
Increased HR, contractility, renin, lipolysis
Beta1 agonist (e.g., dobutamine)
Decreased HR, contractility, renin, lipolysis
Beta1 antagonist (e.g., metoprolol)
- Vasodilation, bronchodilation
- increased HR, contractility, lipolysis, insulin release
- inc aqueous humor prod
- ciliary muscle relaxation
- decreased uterine tone (tocolysis)
Beta2 agonist (e.g., albuterol, terbutaline)
- vaso & bronchoconstriction
- decreased HR, contractility, lipolysis, insulin release
- dec aqueous humor prod
- ciliary muscle contraction (accommodation)
- increased uterine tone
Beta2 antagonist
CNS, enteric nervous system
M1
decreased HR and contractility of atria
M2 agonist
increased HR and contractility of atria
M2 antagonist (e.g., atropine)
increased exocrine gland secretion, gut peristalsis, bladder contraction, bronchoconstriction, pupil constriction, ciliary muscle contraction (accommodation)
M3 agonist
Cholinesterase inhibitor poisoning (i.e., nonselective muscarinic agonist)
DUMBBELS Diarrhea Urination Miosis Bronchospasm Bradycardia Exc of skeletal musc. & CNS Lacrimation Sweating Salivation
Relaxes renal vascular smooth muscle
D1
Modulates transmitter release, especially in the brain
D2
Increased nasal and bronchial mucus production, increased vascular permeability, contraction of bronchioles, pruritus, pain
H1
Increased gastric acid secretion
H2
Increased vascular smooth muscle contraction
V1
Increased H2O permeability and reabsorption in the CTs of the kidney
V2
Atropine toxicity (ie. nonselective muscarinic antagonist)
Hot as a hare Dry as a bone Red as a beet Blind as a bat Mad as a hatter
Which receptors use Gq –> PLC –> IP3 –> increased calcium? (and DAG –> PKC)
H1, alpha1, V1, M1, M3
Which receptors use Gs –> increased cAMP?
Beta1, beta2, D1, H2, V2
Which receptors use Gi –> decreased cAMP?
M2, alpha2, D2
