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0. Step Ia > FA - Key Associations > Flashcards

FA - Key Associations Flashcards

1
Q

Actinic (solar) keratosis

A

Precursor to squamous cell carcinoma

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2
Q

Acute gastric ulcer associated with CNS injury

A

Cushing ulcer (increase intracranial pressure stimulates vagal gastric secretion)

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3
Q

Acute gastric ulcer associated with severe burns

A

Curling ulcer (greatly reduced plasma volume results in sloughing of gastric mucosa)

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4
Q

Alternating areas of transmural inflammation and normal colon

A

Skip lesions (Crohn disease)

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5
Q

Aneurysm, dissecting

A

hypertension

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6
Q

Aortic aneurysm, abdominal and descending aorta

A

Atherosclerosis

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7
Q

Aortic aneurysm, arch

A

3° syphilis (syphilitic aortitis), vasa vasorum destruction

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8
Q

Aortic aneurysm, ascending

A

Marfan syndrome (idiopathic cystic medial degeneration)

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9
Q

Atrophy of the mammillary bodies

A

Wernicke encephalopathy (thiamine deficiency causing ataxia, ophthalmoplegia, and confusi

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10
Q

Autosplenectomy (fibrosis and shrinkage)

A

Sickle cell anemia (hemoglobin S)

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11
Q

Bacteria associated with gastritis, peptic ulcer disease, and stomach cancer

A

H. pylori

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12
Q

Bacterial meningitis (adults and elderly)

A

Streptococcus pneumoniae

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13
Q

Bacterial meningitis (newborns and kids)

A

Newborns: Group B streptococcus, E.coli

Kids: S. pneumoniae, Neisseria meningitidis

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14
Q

Benign melanocytic nevus

A

Spitz nevus (most common in 1st two decades)

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15
Q

Bleeding disorder with GpIb deficiency

A

Bernard-Soulier syndrome (defect in platelet adhesion to von Willebrand factor)

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16
Q

Brain tumor (adults)

A

Supratentorial:
metastasis >
astrocytoma (including GBM) > meningioma >
schwannoma

MaMs

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17
Q

Brain tumor (kids)

A

Infratentorial:
medulloblastoma (cerebellum) or

supratentorial: craniopharyngioma

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18
Q

Breast cancer

A

Infiltrating ductal carcinoma

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19
Q

Breast mass

A

Fibrocystic change, carcinoma (in postmenopausal women)

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20
Q

Breast tumor (benign)

A

Fibroadenoma

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21
Q

Cardiac 1° tumor (kids)

A

Rhabdomyoma, often seen in tuberous sclerosis

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22
Q

Cardiac manifestation of lupus

A

Libman-Sacks endocarditis (nonbacterial, affecting both sides of mitral valve)

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23
Q

Cardiac tumor (adults)

A

Metastasis, 1° myxoma (4:1 left to right atrium; “ball and valve”)

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24
Q

Cerebellar tonsillar herniation

A

Chiari II malformation

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25
Q

Chronic arrhythmia

A

Atrial fibrillation (associated with high risk of emboli)

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26
Q

Chronic atrophic gastritis (autoimmune)

A

Predisposition to gastric carcinoma (can also cause pernicious anemia)

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27
Q

Clear cell adenocarcinoma of the vagina

A

DES exposure in utero

DES is a synthetic estrogen that used to be given to women prevent miscarriage, premature labor, and related complications of pregnancy.

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28
Q

Compression fracture

A

Osteoporosis

type I: postmenopausal woman; type II: elderly man or woman

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29
Q

Congenital adrenal hyperplasia, hypotension

A

21-hydroxylase deficiency

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30
Q

Congenital cardiac anomaly

A

VSD

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31
Q

Congenital conjugated hyperbilirubinemia (black liver)

A

Dubin-Johnson syndrome (inability of hepatocytes to secrete conjugated bilirubin into bile)

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32
Q

Constrictive pericarditis

A

TB (developing world)

SLE (developed world)

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33
Q

Coronary artery involved in thrombosis

A

LAD > RCA > LCA

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34
Q

Cretinism

A

Iodine deficit/hypothyroidism

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35
Q

Cushing syndrome

A
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36
Q

Cyanosis (early; less common)

A

Tetralogy of Fallot
Transposition of great vessels
Truncus arteriosus

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37
Q

Cyanosis (late; more common)

A

VSD, ASD, PDA

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38
Q

Death in CML

A

Blast crisis

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39
Q

Death in SLE

A

Lupus nephropathy

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40
Q

Dementia

A

Alzheimer disease, multiple infarcts

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41
Q

Demyelinating disease in young women

A

Multiple sclerosis

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42
Q

DIC

A

Severe sepsis, obstetric complications, cancer, burns, trauma, major surgery

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43
Q

Dietary deficit

A

Iron

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44
Q

Diverticulum in pharynx

A

Zenker diverticulum (diagnosed by barium swallow)

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45
Q

Ejection click

A

Aortic/pulmonic stenosis

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46
Q

Esophageal cancer

A

Squamous cell carcinoma (worldwide); adenocarcinoma (U.S.)

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47
Q

Food poisoning (exotoxin mediated)

A

S. aureus, B. cereus

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48
Q

Glomerulonephritis (adults)

A

Berger disease (IgA nephropathy)

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49
Q

Gynecologic malignancy

A

Endometrial carcinoma (most common in U.S.)

cervical carcinoma (most common worldwide)

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50
Q

Heart murmur, congenital

A

Mitral valve prolapse

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51
Q

Heart valve in bacterial endocarditis

A

Mitral > aortic (rheumatic fever), tricuspid (IV drug abuse)

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52
Q

Helminth infection (U.S.)

A

Enterobius vermicularis

Ascaris lumbricoides

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53
Q

Hematoma—epidural

A

Rupture of middle meningeal artery (trauma; lentiform shaped)

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54
Q

Hematoma—subdural

A

Rupture of bridging veins (crescent shaped)

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55
Q

Hemochromatosis

A
  • Multiple blood transfusions

- Hereditary HFE mutation (can result in CHF, “bronze diabetes,” and increased risk of hepatocellular carcinoma)

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56
Q

Hepatocellular carcinoma

A

Cirrhotic liver (associated with hepatitis B and C and with alcoholism)

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57
Q

Hereditary bleeding disorder

A

von Willebrand disease

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58
Q

Hereditary harmless jaundice

A

Gilbert syndrome (benign congenital unconjugated hyperbilirubinemia)

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59
Q

HLA-B27

A

Ankylosing spondylitis, reactive arthritis, ulcerative colitis, psoriatic arthritis

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60
Q

HLA-DR3 or -DR4

A

Diabetes mellitus type 1, rheumatoid arthritis, SLE

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61
Q

Holosystolic murmur

A

VSD, tricuspid regurgitation, mitral regurgitation

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62
Q

Hypercoagulability, endothelial damage, blood stasis

A

Virchow triad (results in venous thrombosis)

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63
Q

Hypertension, 2°

A

Renal disease

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64
Q

Hypoparathyroidism

A

Accidental excision during thyroidectomy

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65
Q

Hypopituitarism

A

Pituitary adenoma (usually benign tumor)

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66
Q

Infection 2° to blood transfusion

A

Hepatitis C

67
Q

Infections in chronic granulomatous disease

A

Staphylococcus aureus, E. coli, Aspergillus (catalase +)

68
Q

Intellectual disability

A

Down syndrome, fragile X syndrome

69
Q

Kidney stones

A

Calcium = radiopaque

Struvite (ammonium) = radiopaque (formed by urease +
organisms such as Proteus vulgaris or Staphylococcus)

Uric acid = radiolucent

70
Q

Late cyanotic shunt (uncorrected left –> right becomes right –> left)

A

Eisenmenger syndrome (caused by ASD, VSD, PDA; result in pulmonary HTN and polycythemia)

71
Q

Liver disease

A

Alcoholic cirrhosis

72
Q

Lysosomal storage disease

A

Gaucher disease

73
Q

Male cancer

A

Prostatic carcinoma

74
Q

Malignancy associated with noninfectious fever

A

Hodgkin lymphoma

75
Q

Malignancy (kids)

A

ALL, medulloblastoma (cerebellum)

76
Q

Metastases to bone

A

Prostate, breast > lung > thyroid

77
Q

Metastases to brain

A

Lung > breast > genitourinary > melanoma > GI

78
Q

Metastases to liver

A

Colon&raquo_space; stomach, pancreas

79
Q

Mitochondrial inheritance

A

Disease occurs in both males and females, inherited through females only

80
Q

Mitral valve stenosis

A

Rheumatic heart disease

81
Q

Mixed (UMN and LMN) motor neuron disease

A

Amyotrophic lateral sclerosis

82
Q

Myocarditis

A

Coxsackie B

83
Q

Nephrotic syndrome (adults)

A

Focal segmental glomerulosclerosis

84
Q

Nephrotic syndrome (kids)

A

Minimal change disease

85
Q

Neuron migration failure

A

Kallmann syndrome (hypogonadotropic hypogonadism and anosmia)

86
Q

Nosocomial pneumonia

A

Klebsiella, E. coli, Pseudomonas aeruginosa

87
Q

Obstruction of male urinary tract

A

BPH

88
Q

Opening snap

A

Mitral stenosis

89
Q

Opportunistic infection in AIDS

A

Pneumocystis jirovecii pneumonia

90
Q

Osteomyelitis

A

S. aureus

91
Q

Osteomyelitis in sickle cell disease

A

Salmonella

92
Q

Osteomyelitis with IV drug use

A

Pseudomonas, S. aureus

93
Q

Ovarian metastasis from gastric carcinoma or breast cancer

A

Krukenberg tumor (mucin-secreting signet-ring cells)

94
Q

Ovarian tumor (benign, bilateral)

A

Serous cystadenoma

95
Q

Ovarian tumor (malignant)

A

Serous cystadenocarcinoma

96
Q

Pancreatitis (acute)

A

Gallstones, alcohol

97
Q

Pancreatitis (chronic)

A

Alcohol (adults), cystic fibrosis (kids)

98
Q

Patient with ALL /CLL /AML /CML

A

ALL: child
CLL: adult > 60
AML: adult ∼ 65
CML: adult 30–60

99
Q

Pelvic inflammatory disease

A

Chlamydia trachomatis, Neisseria gonorrhoeae

100
Q

Philadelphia chromosome t(9;22) (bcr-abl)

A

CML (may sometimes be associated with ALL/AML)

101
Q

Pituitary tumor

A

Prolactinoma, somatotropic “acidophilic” adenoma

102
Q

1° amenorrhea

A

Turner syndrome (45,XO)

103
Q

1° bone tumor (adults)

A

Multiple myeloma

104
Q

1° hyperaldosteronism

A

Adenoma of adrenal cortex

105
Q

1° hyperparathyroidism

A

Adenomas, hyperplasia, carcinoma

106
Q

1° liver cancer

A

Hepatocellular carcinoma (chronic hepatitis, cirrhosis, hemochromatosis, α1-antitrypsin deficiency)

107
Q

Pulmonary hypertension

A

COPD

108
Q

Recurrent inflammation/thrombosis of small/medium vessels in extremities

A

Buerger disease (strongly associated with tobacco)

109
Q

Renal tumor

A

Renal cell carcinoma: associated with VHL and cigarette smoking; paraneoplastic syndromes (EPO, renin, PTH, ACTH)

110
Q

Right heart failure due to a pulmonary cause

A

Cor pulmonale

111
Q

S3 (protodiastolic gallop)

A

increased ventricular filling (left-to-right shunt, mitral regurgitation, LV failure [CHF])

112
Q

S4 (presystolic gallop)

A

Stiff/hypertrophic ventricle (aortic stenosis, restrictive cardiomyopathy)

113
Q

2° hyperparathyroidism

A

Hypocalcemia of chronic kidney disease

114
Q

Sexually transmitted disease

A

Chlamydia (usually coinfected with gonorrhea)

115
Q

SIADH

A

Small cell carcinoma of the lung

116
Q

Site of diverticula

A

Sigmoid colon

117
Q

Sites of atherosclerosis

A

Abdominal aorta > coronary artery > popliteal artery > carotid artery

118
Q

Stomach cancer

A

Adenocarcinoma

119
Q

Stomach ulcerations and high gastrin levels

A

Zollinger-Ellison syndrome (gastrinoma of duodenum or pancreas)

120
Q

t(14;18)

A

Follicular lymphomas (bcl-2 activation)

121
Q

t(8;14)

A

Burkitt lymphoma (c-myc activation)

122
Q

t(9;22)

A

Philadelphia chromosome, CML (bcr-abl fusion)

123
Q

Temporal arteritis

A

Risk of ipsilateral blindness due to thrombosis of ophthalmic artery; polymyalgia rheumatica

124
Q

Testicular tumor

A

Seminoma (malignant, radiosensitive)

125
Q

Thyroid cancer

A

Papillary carcinoma

126
Q

Tumor in women

A

Leiomyoma (estrogen dependent, not precancerous)

127
Q

Tumor of infancy

A

Hemangioma (usually regresses spontaneously by childhood)

128
Q

Tumor of the adrenal medulla (adults)

A

Pheochromocytoma (usually benign)

129
Q

Tumor of the adrenal medulla (kids)

A

Neuroblastoma (malignant)

130
Q

Type of Hodgkin

A

Nodular sclerosis (vs. mixed cellularity, lymphocytic predominance, lymphocytic depletion)

131
Q

Type of non-Hodgkin

A

Diffuse large cell

132
Q

UTI

A

E. coli, Staphylococcus saprophyticus (young women)

133
Q

Viral encephalitis affecting temporal lobe

A

HSV-1

134
Q

Vitamin deficiency (U.S.)

A

Folate (pregnant women are at high risk; body stores only 3- to 4-month supply; prevents neural tube defects)

135
Q

acanthocyte

A

liver dz, aß-lipoproteinemia (cholesterol dysregulation)

136
Q

basophilic stippling

A

ACD, OH abuse, lead poisioning, thalassemia

137
Q

bite cell

A

g6pd deficiency

138
Q

elliptocyte

A

hereditary elliptocytosis

139
Q

macro-ovalocyte

A

megaloblastic anemia, marrow failure

140
Q

ringed sideroblast

A

sideroblastic anemia, excess Fe

141
Q

schistocyte, helmet cell

A

DIC, TTP/HUS, traumatic hemolysis (mechanical heart valve)

microangiopathic hemolytic anemia

142
Q

spherocyte

A

hereditary spherocytosis

143
Q

teardrop

A

myelofibrosis

144
Q

target

A

HbC
asplenia
liver dz
thalassemia

“HALT” said the hunter to his target

145
Q

heinz bodies

A

g6pD

146
Q

howell-jolly bodies

A

hyposplenia/asplenia (ie sickle cell)

147
Q

NT ∆’s with alzheimer’s dz

A

decr. ACh

148
Q

NT ∆’s with anxiety

A

incr. NE

decr. GABA, 5HT

149
Q

NT ∆’s with depression

A

decr. NE, 5HT, dopamine

150
Q

NT ∆’s with huntingtons

A

incr. dopamine

decr. GABA, ACh

151
Q

NT ∆’s with Parkinson’s

A

incr. ACh, 5HT

decr. dopamine

152
Q

NT ∆’s with schizophrenia

A

incr. dopamine

153
Q

22q11 syndrome cardiac findings

A

truncus arteriosus, tet. of fallot

154
Q

cardiac findings in down syndrome

A

asd, vsd, av septal defect (endocardial cushions)

155
Q

cardiac findings in congenital rubella

A

septal defects, pda, pulmonary artery stenosis

156
Q

cardiac findings in turner syndrome

A

bicuspid aortic valve, coarctation (pre-ductal)

157
Q

cardiac findings in marfans

A

MVP, aortic aneurysm + dissection, aortic regurg

158
Q

cardiac findings in infant of diabetic mother

A

transposition of the great vessels

159
Q

ECG in anterior wall (LAD)

A

V1-V4

160
Q

ECG in anteroseptal (LAD)

A

V1-V2

161
Q

ECG in anterolateral (LAD, LCX)

A

V4-V6

162
Q

Lateral wall (LCX)

A

I, aVL

163
Q

Inferior wall (RCA)

A

II, III, aVF

164
Q

ß blocker OD remedy

A

glucagon

0. Step Ia (28 decks)

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