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Micro > FA Bugs with Exotoxins I > Flashcards

FA Bugs with Exotoxins I Flashcards

1
Q

Pharyngitis with pseudomembranes in throat and severe LAD (bull neck)

A

Corynebacterium diphtheriae

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2
Q

ADP ribosylating A-B toxin

A

Diphtheria toxin OR exotoxin A (pseudomonas)

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3
Q

What does the B component of the diphtheria toxin do?

A

(Binding) binds to host cell surface receptor, enabling endocytosis

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4
Q

What does the A component of the diphtheria toxin do?

A

(Active) attaches ADP-riboxyl to disrupt host cell proteins

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5
Q

What is the mechanism of diphtheria toxin?

A

Inactivate elongation factor (EF-2), thus inhibiting protein synthesis

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6
Q

With what bug is exotoxin A associated?

A

Pseudomondas aeuruginosa

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7
Q

What is the manifestation of exotoxin A action?

A

Host cell death

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8
Q

What is the mechanism of exotoxin A?

A

Inactivate EF-2 –> inhibit protein synthesis

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9
Q

What is the mechanism of Shiga toxin (ST)?

A

Inactivate 60S ribosome by removing adenine from rRNA

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10
Q

What does Shiga toxin do?

A

GI mucosal damage –> dysentery ST also enhances cytokine release, causing HUS

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11
Q

With what bug is Shiga-like toxin (SLT) associated

A

EHEC (incl O157:H7)

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12
Q

What is the mechanism of SLT?

A

Inactivate 60S ribosome by removing adenine from rRNA

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13
Q

What toxins inactivate 60S ribosome by removing adenine from rRNA?

A

Shiga and shiga-like toxins

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14
Q

What does SLT do?

A

Enhances cytokine release, causing HUS; unlike shigella, SLT does NOT invade host cells

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15
Q

What three bugs are associated with exotoxins that increase fluid secretion?

A

ETEC, bacillus anthracis, vibrio cholerae

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16
Q

What four bugs are associated with exotoxins that inhibit protein synthesis?

A

Diphtheria, Pseudomonas, Shigella, EHEC

17
Q

What bug has a toxin that inhibits phagocytic ability?

A

Bordetella pertusis

18
Q

What bugs have exotoxins that inhibit release of neurotransmitter?

A

Clostridium tetani, clostridium botulinum

19
Q

What bugs have exotoxins that lyse cell membranes?

A

clostriudium perfringens,

streptococcus pyogenes

20
Q

What bugs have exotoxins that are super antigens causing shock?

A

Staph aureus

Strep pyogenes

21
Q

ETEC exotoxins

A

Heat-labile toxin (LT)

Heat-stabile toxin (ST)

22
Q

bacillus antracis exotoxin

A

Edema factor

23
Q

Vibrio cholerae exotoxin

A

cholera toxin

24
Q

Bordetella pertussis exotoxin that inhibits phagocytic ability

A

Pertussis toxin

25
Q

Clostridium tetani exotoxin that inhibits release of NT

A

Tetanospasmin

26
Q

Clostridium botulism exotoxin that inhibits release of NT

A

Botulinum toxin

27
Q

Clostridium perfringens exotoxin that lyses cell membranes

A

Alpha toxin

28
Q

Strep pyogenes exotoxin that lyses cell membranes

A

Streptolysin O

29
Q

Staph aureus exotoxin

A

TSST-1

30
Q

Strep pyogenes exotoxin that is a super antigen causing shock

A

Exotoxin A (the same one as Pseudomonas?!)

Micro (21 decks)

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