FA Bugs with Exotoxins I Flashcards
Pharyngitis with pseudomembranes in throat and severe LAD (bull neck)
Corynebacterium diphtheriae
ADP ribosylating A-B toxin
Diphtheria toxin OR exotoxin A (pseudomonas)
What does the B component of the diphtheria toxin do?
(Binding) binds to host cell surface receptor, enabling endocytosis
What does the A component of the diphtheria toxin do?
(Active) attaches ADP-riboxyl to disrupt host cell proteins
What is the mechanism of diphtheria toxin?
Inactivate elongation factor (EF-2), thus inhibiting protein synthesis
With what bug is exotoxin A associated?
Pseudomondas aeuruginosa
What is the manifestation of exotoxin A action?
Host cell death
What is the mechanism of exotoxin A?
Inactivate EF-2 –> inhibit protein synthesis
What is the mechanism of Shiga toxin (ST)?
Inactivate 60S ribosome by removing adenine from rRNA
What does Shiga toxin do?
GI mucosal damage –> dysentery ST also enhances cytokine release, causing HUS
With what bug is Shiga-like toxin (SLT) associated
EHEC (incl O157:H7)
What is the mechanism of SLT?
Inactivate 60S ribosome by removing adenine from rRNA
What toxins inactivate 60S ribosome by removing adenine from rRNA?
Shiga and shiga-like toxins
What does SLT do?
Enhances cytokine release, causing HUS; unlike shigella, SLT does NOT invade host cells
What three bugs are associated with exotoxins that increase fluid secretion?
ETEC, bacillus anthracis, vibrio cholerae
What four bugs are associated with exotoxins that inhibit protein synthesis?
Diphtheria, Pseudomonas, Shigella, EHEC
What bug has a toxin that inhibits phagocytic ability?
Bordetella pertusis
What bugs have exotoxins that inhibit release of neurotransmitter?
Clostridium tetani, clostridium botulinum
What bugs have exotoxins that lyse cell membranes?
clostriudium perfringens,
streptococcus pyogenes
What bugs have exotoxins that are super antigens causing shock?
Staph aureus
Strep pyogenes
ETEC exotoxins
Heat-labile toxin (LT)
Heat-stabile toxin (ST)
bacillus antracis exotoxin
Edema factor
Vibrio cholerae exotoxin
cholera toxin
Bordetella pertussis exotoxin that inhibits phagocytic ability
Pertussis toxin
Clostridium tetani exotoxin that inhibits release of NT
Tetanospasmin
Clostridium botulism exotoxin that inhibits release of NT
Botulinum toxin
Clostridium perfringens exotoxin that lyses cell membranes
Alpha toxin
Strep pyogenes exotoxin that lyses cell membranes
Streptolysin O
Staph aureus exotoxin
TSST-1
Strep pyogenes exotoxin that is a super antigen causing shock
Exotoxin A (the same one as Pseudomonas?!)
