Extras: Study Sheets: Tumors

Question 1

three types of gliomas + the breakdown of each of those

Answer 1

1. astrocytomas: infiltrating, pilocytic, glioblastoma
2. oligodendrogliomas
3. ependymomas: anaplastic, myxopapillary, subependymoma

Question 2

three gliomas that appear in childhood (rest are mostly adult)

Answer 2

pilocytic astrocytoma, glioblastoma, ependymoma

Question 3

GFAP seen in which type of cancer

Answer 3

astrocytmas

Question 4

two gliomas that are ring enhancing on CT

Answer 4

glioblastoma, ependymomas

Question 5

three histo hallmarks of glioblastoma

Answer 5

1. serpentine necrosis
2. pseudo-pallisading
3. VEGF vascular and endothelial prolif

Question 6

MC location for ependymoma

Answer 6

4th ventricle

Question 7

type of tumors that cause medically-refractory epilepsy

Answer 7

neuronal tumors: gangliomas, DNET

Question 8

where is DNET found

Answer 8

superficial temporal lobes

Question 9

what tumor causes drop metz to cauda equina?

Answer 9

medulloblastoma

Question 10

what tumor is 100% radiosensitive?

Answer 10

medulloblastoma

Question 11

two histo characteristis of medulloblastoma

Answer 11

1. Homer-wright rosettes

2. cell wrapping

Question 12

three histo findings of AT/RT

Answer 12

EMA, Vimentin, Rhabdoid cells

Question 13

histo of primary CNS lymphoma

Answer 13

hooping

Question 14

what to look for with germ cell tumors

Answer 14

metz from testes

Question 15

what CA can be majorly increased in pregnancy bc of Progesterone receptors?

Answer 15

meningioma

Question 16

two histo findings of meningioma

Answer 16

1. calcified psammoma bodies

2. whorled clusters of monotonous cells

Question 17

five MC places for metz to brain

Answer 17

lung, breast, melanoma, GI, kidney

Question 18

location for schwannomas

Answer 18

cerebellar pontine angle

Question 19

what CA stains for S100 + has antoni A and B dense/loos areas

Answer 19

schwannomas

Question 20

three types of Neurofibromas and describe

Answer 20

1. superficial cutaneous: pedunculated
2. diffuse: plaque like elevations of skin
3. plexiform: associated with nerve roots, looks like bag of worms

Question 21

chromosome for: NF1, NF2, and VHL

Answer 21

1. NF1: 17q11
2. NF2: 22q12
3. VHL: 3p25

Question 22

chromosome for: NBCCS, Tuberous Sclerosis, and Cowden syndrome

Answer 22

1. NBCCS: 9q2
2. Tuberous sclerosis: 9q34, 16p13
3. Cowden syndrome: 10q23

Question 23

protein involved in Nevoid BCC and Cowden syndrome

Answer 23

1. nevoid BCC: PTCH

2. Cowden: PTEN

Question 24

five characteristics of NF1 and four characteristics of NF2

Answer 24

1. NF1: neurofibromas, pheochromocytoma, cafe au lait, optic N glioma, Lisch nodules on iris
2. NF2: neurofibromas, multiple meningioma, ependymoma, acoustic neuromas (CN8 schwannomas)

Question 25

five features of Von Hippel Lindau

Answer 25

1. hemangioblastoma
2. RCC
3. pancreatic neoplasm
4. polycythemia
5. cysts in liver/panc/kidneys

Question 26

what condition is cardiac rhabdomyoma seen in?

Answer 26

tuberous sclerosis