Extras: Breasts

Question 1

one tx for mastalgia

Answer 1

danazol

Question 2

five non prolif vs five prolif without atypia breast masses

Answer 2

1. non-prolif: fibrocystic change, adenosis, lactational adenoma, fibroadenoma, galactocele
2. prolif without atypia: ep hyperplasia, sclerosing adenosis, complex sclerosing lesions, papillomas, gynecomastia

Question 3

MC benign breast tumor

Answer 3

fibroadenoma

Question 4

two things that have a MED12 mutation

Answer 4

leiomyoma, fibroadenoma of breast

Question 5

histo of sclerosing adenosis

Answer 5

acini in a swirled pattern, compressed by dense stroma

Question 6

papilloma presentation

Answer 6

serous or serosanguinous discharge

Question 7

mutation in LCIS

Answer 7

CDH1 -> loss of E cadherins

Question 8

subtypes of CA most associated with BRCA1 vs 2 mutations

Answer 8

1. BRCA1: triple negative

2. BRCA2: Luminal