Exotoxin vs. Endotoxin

Question 1

Where does exotoxin come from?

Answer 1

from both gram + and - bacteria

Question 2

Where does endotoxin come from?

Answer 2

Outer cell membrane of gram - (LPS)

Question 3

Is exotoxin secreted from cell?

Answer 3

yes

Question 4

Is endotoxin secreted from cell?

Answer 4

no

Question 5

what is exotoxin made of?

Answer 5

polypeptide

Question 6

what is endotoxin made of?

Answer 6

lipopolysaccharide (structural part of bacteria, released when lysed)

Question 7

location of genes for exotoxin?

Answer 7

plasmid or bacteriophage

Question 8

loaction of genes for endotoxin?

Answer 8

bacterial chromosome

Question 9

what is the toxicity of exotoxin?

Answer 9

high, fatal dose on the order of 1 ug

Question 10

what is the toxicity of endotoxin?

Answer 10

low, fatal dose on the order of hundreds of micrograms

Question 11

what are the clinical effects of endotoxin?

Answer 11

fever, shock (hypotension), DIC

Question 12

endotoxin induces

Answer 12

TNF, IL-1, IL-6

Question 13

explain the antigenicity of exotoxin

Answer 13

induces high-titer antibodies called antitoxins

Question 14

explain the antigenicity of endotoxin

Answer 14

poorly antigenic