Exam II- Spring 2024 Flashcards
Identify the 5 anatomical structures
- Central Tendon
- Esophageal Aperture
- Lumbar Spine- where diaphragm anchors itself to
- Aortic Aperture
- Caval Aperture
*alternate view
Identify the 5 anatomical structures
- Epiglottis
- Thyrohyoid Membrane and Hyoid Bone
- Thyroid Cartilage
- Cricoid Cartilage
- Laryngeal Prominence (Adam’s Apple)
Identify the 7 Anatomical Structures
- Epiglottis
- Cricoid Cartliages
- Vocal Folds (vocal cords)
- Thyroid Cartilage
- Thyrohyoid Ligament
- Hyoid Bone
- Tracheal Cartilage
Identify the 2 anatomical structures
- Colliculus
- Thyroid Cartilage
lateral view
What type of muscles are in the vocal folds and what innervates them?
- Skeletal muscles
- Recurrent laryngeal nerve
What is the formula to calculate Transpulmonary Pressures (PTP)? What other pressure does this formula work for?
- PTP= Aveolar Pressure (PA) - Pleural Pressure (PIP)
- Elastic Pressure (PEL)
What is the formula for Tidal Volume?
What is the formula in minute ventilation?
What are the normal values for each?
- VT= VDS + VA
- Minute Vent= VT x (RR)
- Resp. Rate= 12 bpm
- Tidal Volume= 500 mL; 6 L/min
- Dead Space Volume= 150 mL; 1.8 L/ min
- Aveolar Volume= 350 mL; 4.2 L/ min
What are the normal volumes for:
Tidal Volume
Residual Volume
Expiratory Reserve Volume
Inspiratory Reserve Volume
- TV= 500 mL
- RV= 1.5 L
- ERV= 1.5 L
- IRV= 2.5 L
Which volumes make up the following capacities and their normal values:
Total Lung Capacity
Inspiratory Capacity
Functional Residual Capacity
Working/ Vital Capacity
- TLC= 6 L
- IC= IRV+VT= 3.0 L
- FRC= ERV+RV= 3.0 L
- VC= IRV+VT+ERV= 4.5 L
definitions: P, C, a, A, V
A: alveolar
a: arterial
C: content
P: pressure
V: ventilation
1 atm =?
760mmHg
PA>Pv>Pa
- West Perfusion Zone 1
- no blood flow
- In a healthy lung, there should not be a zone 1
Pa>PA>Pv
- West Perfusion Zone 2
- Pulsatile flow; “In between”
- Pulsatile blood flow during higer pressures times of the cardiac cycle and tapers off with a lower pulm blood pressure
- top portions of the lung
Pa>Pv>PA
- West Perfusion Zone 3
- Continuous flow; “always on”
- Normally in the bottom 1/2 of the lung
The effects of the weight of the lung on blood flow at the very base of the lung that sites on the diaphragm
- West Perfusion Zone 4
- A subset of Zone 3; reduces the amount of blood flow in the very bottom portion of the base
- the weight of the lungs compress the easily collapsable pulm vein and arteries
Primary muscle for inpiration and ventilation
Diaphragm
Supportive muscles that aid in inspiration? Expiration?
- Intercostal and scalene muscles
- Only intercostal muscles
How many scalene muscles are there and where are the attachment points?
- 3 Scalene Muscles
- 5: Anterior; C3-C6 and attach to Rib 1
- 6: Middle; C3-C7 and attach to Rib 1
- 7: Posterior; C5-C7 and attach to Rib 2
Describe the diaphragm, innervation, and where is it attached?
- Dome-shaped striated skeletal muscle that is thought of as two leaflets or domes
- Phrenic nerve
- Anchored into the L-spine bodies
What are the three openings and their orientation in the body?
- Caval Aperture- most anterior
- Aortic Aperture- most posterior
- Esphogeal Aperture- between the two
Which aperture is most anterior and which is most posterior?
- Caval Aperture is most anterior
- Aortic Aperture is most posterior
What is the largest cartilaginous part of the larynx (voice box)?
- Thyroid Cartilage
During growth and development, _____ segments in the ______ lung fuse together.
4; left
Generation 0-16 is known as the ______.
Generation 0 is the ______.
- Conducting Zone
- Trachea
What are airways with no cartilage?
Bronchioles
Starting from the trachea, list the path of air during inspiration.
Trachea> bronchi> bronchioles> terminal bronchioles> respiratory bronchioles> alveolar ducts> alveolar sacs
Vocal cords are fastened anteriorly at the ______.
Thyroid cartilage
The larynx is innervated by what nerve?
Recurrent laryngeal nerve
Generations 17-23 are known as ?
Transitional and Respiratory Zones
starting generation point for alveoli to show up
generation 17
How many generations total do we have?
24; trachea is zero
All the surface area of all the alveoli of the lungs equals ________.
70 m^2
how many alveoli sacs are there?
8x10^6
The lungs have _______ more capacity for gas exchange if it needs it.
3x
When does cyanosis occur as it pertains to deoxyhemoglobin?
When deoxyhemoglobin >5 g/ dL
What is the Fick Equation?
CO= O2 absorbed per min (mL/ min)/ Arteriovenous O2 difference (ml/ L)
What volumes make up the vital capacity?
Expiratory Reserve Volume (ERV), Tidal Volume (TV), and Inspiratory Reserve Volume (IRV)
What volumes make up functional residual capacity (FRC)?
ERV , RV
(+) air flow value
expiratory follow,
(-) is inspiratory
lowest/highest airflow and at what time marks
1 second: -0.5L/s
3 second: +0.5L/s
highest alveolar pressure and at what time marks
1 second: -1 cm H2O
3 second: +1 cm H2O
Alveolar capillaries resistance gets higher as ___ , it gets lower as ___
Alveolar resistance gets higher as lung volumes get higher , gets lower as lung volume gets lower
Higher the pulmonary blood flow, the lower?
PVR
the two ways that our body uses to reduce pulmonary vascular resistance when cardiac output increases.
recruitment and distension
effect on PVR from increased lung volume
increase
effect on PVR from decreased lung volume
increase
effect on PVR from increased pulmonary artery pressure
decrease
effect on PVR from increased left atrial pressure
decrease
In gravity dependent regions of the lungs, PVR increase or decrease
decreases
effect on PVR from positive pressure ventilation
increases
% of gases in atmosphere
N2: 79%
O2: 21%
CO2: 0.04%
water vapor pressure during humidification
47 mmHg
the alveolar gasses should be the same as ?
the alveolar gasses should be the same as our pulmonary venous gasses or our systemic arterial gasses.
in deoxygenated venous blood PO2 =
40 mmHg
venous PCO2 =
45 mmHg
arterial blood PaO2 = ?
100 mmHg
arterial blood PaCO2 =
40 mmHg
pulmonary capillary pressures
HPV is primarily done thru sensing which gas?
O2
secondary : CO2
greater intravascular pressures
more recruitment, distention
lower resistance
greater blood flow
perfusion of bottom lung
intrapleural pressure less negative
smaller transmural pressure gradient
alveoli smaller, more compliant
more ventilation
ventilation of bottom lung
top of lung doesnt get emptier than ?
bottom lung doesn’t get emptier than ?
top: 30%
bottom: 20%
FRC intrapleural pressure:
RV intrapleural pressure:
FRC: -5 cm H2O
RV: +2 cm H2O
noble gas used for PFT
Xenon
noble gas thats 2nd leading cause of lung cancer
Radon
makes up 62% of all surfactant’s phospholipids
phosphatidylcholine and dipalmitoyl phosphatidylcholine
hydrophobic surfactant protein
SP-B and SP-C
surfactant make up % between protein and lipids
90% lipid, 10% protein
functions of club cells
produces surfactant at much lower rate than alveoli
progenitor cell for damaged areas of lung
elastic recoil pressure components
1/3 is d/t tissue recoil
2/3 is d/t surface tension
type 1 vs type 2 alveolar cell surface area percentage
type 1: 90-95% of alveolar surface area
type 2: 5-10% of alveolar surface area
Not only does COPD not have enough elastic tissue in alveoli and airways, it also has less?
traction
increasing lung volume does what to airway resistance?
decreases
FRC volumes standing vs supine
standing: 3L
supine: 2L
what happens to FRC as head of bed is tilted down
decreases
FRC drops in supine pt because of?
reduction in ERV
“diaphragm is getting pushed up from all the mass of the stuff that’s in your abdomen. So the volume that gets squeezed out is the ERV. “
compliance value for lungs
200 mL/ per cm H2O
__ % of expired air should be CO2
5%
at what transpulmonary pressure will lung be typically full
25-30