A/P Lect 4 Flashcards
What type of channel is nicotinic acetylcholine receptor?
simple diffusion
positive charged specific ion channel (Na, K, Ca)
on all skeletal muscles
what type of channel is aquaporin
simple diffusion
What type of channel is GLUT -1? location?
Facilitated diffusion, in BBB and RBCs
What type of channel is GLUT -4
Facilitated diffusion, skeletal muscle, liver, and fat, primarily skeletal and fat
What type of channel is GLUT - 3
neurons
What type of channel is GLUT-2
hepatocytes, liver and pancreas
which GLUTs are always available?
123
which are the primary active transport pumps?
NA K ATPase, Ca ATPase
which are the secondary active transport pumps?
Ca and Na exchanger, SGLTs
secondary active transporters are almost always dependent on?
sodium gradient
insulin doesn’t have any affect on what?
glucose transport system of the CNS, indirectly affects ability of brain to get glucose if body eats it up
which transporter is insulin dependent and what does it mean?
GLUT 4 only inducible by insulin, only in cell wall when needed
exchange rate for Na and Ca pump
3 Na going in for 1 Ca going out
rate of SGLT1 vs SGLT 2
SGLT2: 1Na and 1Gluc
SGLT1: 2Na and 1 Gluc
which process uses the most atp
Na K ATPase
how does Na K ATpase work as a diuretic?
as Na is pumped out, water wants to follow via osmosis
what contributes to resting membrane potential
concentration gradient created by Na K ATPase, and protein gradient since proteins are negative
what does nernst equation signify
what a single ion contributes to the resting membrane potential
most important ion in context of resting membrane potential
Potassium
