A/P exam 3 Flashcards
bbf rate
750-900ml/min
brain is __ of body weight
2%
750 is __% of CO
15
brain autoregulation LLA and ULA
LLA: 65, ULA: 150
gray matter receives ___% nutrients, white matter gets ___%
80, 20
CO2 combines with ___ dissociates into ___
combines with water to dissociate into bicarb and protons
For each mmPaCO2 change
2-4% change in cerebral blood flow
each degree Celcius temp drops,
reduce oxygen demand by 6 to 7%
list of vasodilators
acetylcholine, ketamine, inhalational anesthetics (isoflurane, desflurane, sevoflurane), Nitrous oxide,
vasoconstrictors
serotonin, propofol/barbiturates,
COW supplied by ?
basilar and two internal carotid arteries
3 cerebellar arteries, which come off basilar and vertebral
superior and anteriorinferior cerebellar artery come off basilar
posterior inferior cerebellar artery come off vertebral
anterior vs posterior spinal artery % flow
anterior gives 75% blood flow, posterior gives 25% split between 2 so 12.5 each
GRA named after?
supplies?
polish guy
artery of adamkiewicz
great radicular artery
great anterior segmental artery
2/3 bottom of spinal cord, especially the anterior
GRA originates between?
T9-T12: 75%
T5 - L5: 25%
3 sources for posterior spinal arteries
cerebellar arteries, specifically posterior inferior cerebellar artery
vertebral arteries and radicular arteries
the
anterior spinal artery source
vertebral arteries at top and anterior radicular arteries at lower levels
SCPP = ?
distal aortic pressure - CSF pressure
spinal cord LLA and ULA
LLA 50, ULA 125
lateral inhibition pressure sensor type
A-beta, pain tracts run next to DCML
nervous system filters ___
97%
feed arteries in c spine, t spine, lumbar
C: 1-2
T: 2, 1 high and other is GRA
L: 1-2, radicular lumbosacral arteries
Golgi stretch organs located in?
tendons
golgi tendon organs
golgi stretch or tension sensors
example for tendon reflex
weight at 90 degree angle
limits of thermal pain
greater than 45C and less than 5C
appendix pain travel path
T10 is where visceral pain enters the cord
L1 is where parietal pain enters cord
anatomy of pain sensing neuron
pseudo-unipolar cell
AMPA located?
second-order neuron in dorsal horn
AMPA ion flow
sodium major player, permits K flow
NMDA ion flow
sodium and calcium
antagonists of NMDA receptor
Ketamine, nitrous, tramadol, lead, alcohol also inactivates them
glycogen found where
skeletal muscle and liver
length of smooth muscle
shorter
SR in smooth muscle
less developed, more reliant on outside Ca
smooth muscle actin myosin
skeletal 2:1
10-20:1
latch mechanism
smooth muscle able to generate lots of force for long periods of time using very little energy
smooth muscle examples
pupillary diameter, airway resistance, vascular smooth muscle (giving rise to SVR), intestines
esophagus made up of?
hybrid of skeletal and smooth muscle
visceral smooth muscle characteristics
act in coordinated way for peristalsis
electrical connections with gap junctions
3 layers of blood vessel
tunica intima, tunica media,
tunica adventitia/externa
(single endothelial layer)
which vessel doesnt have smooth muscle
capillaries