EXAM 5 Flashcards
which ion is greater concentrated on the inside of the cell
K
which ion is greater concentrated on the outside of the cell
Na
what is the intracellular concentration of Na
10 mM
what is the extracellular concentration of Na
140 mM
what is the intracellular concentration of K
140 mM
what is the extracellular concentration of K
2.5 mM
which ion is permeable across the membrane
K
what is the resting membrane potential
-70 mV
does ATPase pump Na in or out of the cell
Out
does ATPase pump K in or out of the cell
in
how many Na and K are pumped in and out of the cell
3 Na out, 2 K in
what kind of ion channels are located in the cell body and dendrites
ligand or mechanically gated
what kind of ion channels are located in the axons of the neuron
voltage gated ion channels
how are ligand channels in the dendrites opened or closed
by neurotransmitter binding or mechanosensation
how are voltage gated channels in the axons opened or closed
by membrane depolarization 21
what is the importance of refractory periods
establish rate of ap propogation and ensure forward propogation of ap
22
1
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first step in generating an action potential
local changes in the cells membrane potential (graded potentials) either hyperpolarize or depolarize
where do graded potential occur
in the dendrites and cell bodies
second step in action potential generation
at the axon hillock, when depolarized to the threshhold value, a population of Na+ voltage gated channels will open, as Na enters, the cell becomes more depolarized causing an action potential to form
3rd step in generation of an action potential
After Na channels open, they close right after
4th step in generation of an action potential
depolarization also causes K voltage gated channels to open, this causes the membrane potential to get negative again