Endocrine/Digestive Flashcards
what are the 5 endocrine glands
pitutary, thyroid, parathyroid, adrenal, pineal
what is an exocrine gland
secretes products into ducts or lumens to the outer surface of the body
what is an endocrine gland
secrete products into interstitial fluid which diffuse into blood
what are local hormones
act locally on neighboring cells or the same cell that secreted them
what is paracrine hormone
when the hormone is relsed onto a neighboring cell
what is autocrine signaling
when the hormone is released onto the same cell that secreted it
how do lipid soluble hormones travel in the bloodstream
they have to bind to a protein
what are the two types of circulating hormones
lipid soluble and water soluble
what are the two kinds of lipid soluble hormones
steroid and thyroid hormones’
what are steroid hormones derived from
cholesterol
what are examples of steroid hormones
cortisol, testosterone, estrogen, progesterone, and aldosterone
what are thyroid hormones derived from
a tyrosine ring with iodine attached
what are the two types of water soluble hormones
peptide/protein hormones and biogenic amines
what are examples of peptide hormones
ADH, oxytocin, hGH, TSH, ACTH, insulin, glucagon
where do biogenic amines come from
modified amino acids
what are examples of biogenic amines
NE, epinephrine, dopamine, serotonin, melatonin, histamine
what is the mechanism of lipid soluble hormones
intracellular receptors, this new complex alter gene expression and specific proteins are created in response.
how do peptide hormones work
bind to an receptor on cell surface, trigger a cascade of protein reactions
how does the hypothalamus control the anterior pituitary gland
releases, relesasing hormones or inhibiting hormones that act on cell s in the anterior pituitary
how does the hypothalamus control posterior pituitary gland
hypothalamus relseases other hormones directly into circulation through posterior pitutary
what are the 5 main cell types in the anterior pituitary
somatotrophs, thyrotrophs, lactotrophs, gonadotrophs, corticotrophs
what do somatotrophs secrete
human growth hormone
thyrotrophs secrete
thyroid simulating hormone
lactotrophs secrete
prolactin
gonadotrophs secrete
follicle stimulating hormone and luteinizing hormone
coroticotrophs secrete
adrenocorticotropic hormone and melanocyte stimulating hormone
what happens in the target cells of human growth hormone
increases synthesis of insulin like growth factors
what do insulin like growth factors do
increase cell growth and cell division, uptake amino acids, increase synthesis of proteins, stimulate lipolysis in adipose tissue, decrease glucose in body and save it for brain
what regulates human growth hormone release
GHRH and GHIH
what is stimuli for the releases of GHRH
hypoglycemia, decreases fatty acids, increased amino acids
what is stimuli for the release of of GHIH
hyperglycemia, increased fatty acids and decreased amino acids in blood, high levels of human growth hormone
what does GnRH (gonadotropin releasing hormone) do
stimulates gonadotrophs to produce follicle simulating hormone or luteinizing hormone
what does FSH do in females
stimulates secretion of estrogen, initiates formation of follicle in the ovary
what does FSH do in males
stimulates sperm production
what does LH do in females
secretion of estrogen and progestrone, ovulation, formation of corpus lutetium
what does LH do in males
secretion of testosterone
what does PRH do
stimulates lactotrophs to produce prolactin
what does prolactin do
causes milk production
what does CRH (corticotropin releasing hormone) do
stimulates corticotrophs to release adrenocorticotropic hormone
what does ACTH
stimulates release of glucocorticoids from adrenal cortex
what does TRH do
stimulates thyrotrophs to produce TSH
what does TSH do
stimulate secretion of T3 and T4
does the posterior pituitary gland synthesize hormones
no
what is the posterior pituitary gland made of
two groups of hypothalamic neurons
What are the two hormones released by the posterior pituitary gland
ADH/vasopressin and oxytocin
where is ADH produced
by cells in the supraoptic nucleus
what are the actions of ADH
decreases urine production by stimulating kidneys to return water, prevents water loss in sweat glands, constriction of arterioles
what triggers release of ADH
dehydration or high blood osmolarity
when is ADH inhibited
overhydration or low osmolarity of blood
where is oxytocin produced
cells of the paraventricular nucleaus
describe the regulation of oxytocin during child birth
stretching of the cervix by baby’s head causes the release of oxytocin, the oxytocin causes the uterus to contract, the babys head is pushed further down the cervix causing oxytocin to be released even more
how does oxytocin effect breast feeding
causes milk to be ejected from mammary glands
which thyroid cells produce T3 and T4
follicular cells
what are the actions of thyroid hormones
increases BMR by stimulating cells to use oxygen to make ATP, increased cellular consumption of glucose, fatty acids, and triglycerides. create more Na/K ATPase, enhance actions of sympathetic nervous system
how does thyroid hyposecretion effect children
dwarfism and severe mental retardation
how does thyroid hyposectrion effect adults
edema, low heart rate, muscle weakness, cold, low body temp, weight gain
symptoms of hypersecretion of thyroid
weight loss, nervousness, tremors, increased heart rate and blood pressure, high body temp
what is goiter
enlarged thyroid gland due to lack of iodine in the diet
calcitonin is secreted by what cell in the thyroid gland
parafollicular cells or c cells