Exam 4

Question 1

antiplatelets

Answer 1

-cox-1 (A)
-ADP inhibitors (TCP TC)
-GP IIb/IIIb inhibitors (TEA)
-PDE inhibitors (DC)
-PAR inhibitors (V)

Question 2

Aspirin

Answer 2

-cox-1
-antiplatelet
-inhibit TXA2
-acute coronary syndrome
-acute stroke
-prevent CVD (thrombosis)
-adj to thromboLYTIC therapy
-alt to anticoagulation in afib
-max dose: 50-320mg/day

Question 3

ADP drugs

Answer 3

-Ticlopidine
-Clopidogrel
-Prasugrel
-Ticagrelor
-Cangrelor (IV)

Question 3

PDE drugs

Answer 3

-dipyridamole
-cilostazole

Question 4

Par drug

Answer 4

V

Question 5

Anticoagulants

Answer 5

-Heparin/Fonaparinux
-Xa inhibitors
-vit k antagonists
-DIT

Question 6

Warfarin

Answer 6

-inhibits II, VII, IX, X
-36-48h

Question 7

facotr xa

Answer 7

-Rivaroxaban
-Apixaban
-Edoxaban
-Betrixaba

Question 8

DTI

Answer 8

-dabigatran
-agr
-bivalrudin

-reversible

Question 9

Fibrinolytics

Answer 9

-T-PA (converts plasminogen to plasmin)
-Alteplase
-Reteplase
-Tenecteplase

Question 10

Antifibrinolytics

Answer 10

-aminocarpoic acid
-tranexamic acid
-Lysine

Question 11

Renal adjustmenys

Answer 11

-argabatran
-fondaparinux
-lepirudin (<60)

Question 12

UFH dosing

Answer 12

-80 units/kg bolus
-18 unit/kg/hr
-(<1.2)<35s: 80/+4
-(1.2-1.4)35-45: 40/+2
-2.6-3(71-90): dec infusion rate by 2

Question 13

fondaprinux dosing

Answer 13

-2.5mg sq prophylactic
-5,7.5,10mg based on weight for tx

Question 14

warfarin reversal

Answer 14

1. 30IU/kg PCC + 1mg/min vit k (check INR before and 30-60min after
2. 10-15ml/kg FFP
3. 1mg/min IV vit k
4. 5mg vit k po
5. omit warfarin (no vit k)

Question 15

Argatroban dosing

Answer 15

-2mcg/kg/min
-HIT
-0.5 in liver dysfunction
-overlap w warfarin until INR>4

Question 16

Lepirudin dose

Answer 16

-0.15mg/kg/h + 0.4mg/kg bolus
-dec if CrCl<60
-HIT

Question 17

Enoxaparin dosing

Answer 17

-30mg BID surgery
-40mg qd medical
-1mg/kg BID tx
-1.5mg/kg qd x
-30mg or 1 mg qd for renal probs

Question 18

Dalteparin dosing

Answer 18

-2500-5000 units
-200units/kg to 150
-SQ

Question 19

Protamine

Answer 19

UFH: 1mg for every 100 units given over past 3 hours
LMWH: 1/100 antixa and 1/1 (0.5 iafter 8 hours)

Question 20

Dabigatran hip dosing

Answer 20

-110mg day of surgery
-220mg maintenance 28-25 days

-150mg BID for everything else (half if crcl 15-30)
-5-10days IV anticoagulation for tx

Question 21

Rivaroxaban dosing

Answer 21

-20mg qd (afib)(prevention)
-10mg qd (prophylaxis 31-39 days)
-15mg BID x3 weeks then 20mg qd (tx)
-avoid CrCl<30

Question 22

Apixaban dosing

Answer 22

-5mg BID(afib)
-2.5mg if over 80 years, under 60kg, SCr >1.5
-10mg BID x 7days then 5mg BID (Tx)
-2.5 BID (prevention)

Question 23

Edoxaban dosing

Answer 23

-60mg qd
-30mg if under 60kg
-requires 5-10 days iv anticoagulation for tx
-dont use if CrCl>95