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Therapeutics II > Dyslipidemia drugs (Lab) > Flashcards

Dyslipidemia drugs (Lab) Flashcards

1
Q

Atorvastatin brand name

A

Lipitor

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2
Q

Rosuvastatin brand name

A

Crestor

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3
Q

Simvastatin brand

A

Zocor

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4
Q

Pravastatin brand

A

Pravachol

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5
Q

Lovastatin brand

A

-Altoprev
-Mevacor

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6
Q

Pitavastatin brand

A

Livalo

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7
Q

Fluvastatin brand

A

Lescol

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8
Q

Statins

A
  • -Atorvastatin (Lipitor)
    -Rosuvastatin (Crestor)
    -Simvastatin (Zocor)
    -Pravastatin (Pravachol)
    -Lovastatin (Altoprev, Mevacor)
    -Pitavastatin (Livalo)
    -Fluvastatin (Lescol)
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9
Q

Cholesterol absorption inhibitors

A

-ezetimibe (Zetia)

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10
Q

Ezetimibe brand

A

Zetia

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11
Q

PSCK-9 inhibitors

A

EvolocuMAB (Repatha)
AlirocuMAB (Praluent)

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12
Q

Evolocumab brand

A

Repatha

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13
Q

Alicorumab brand

A

Praluent

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14
Q

Bile aCid sequestrants

A

-Cholestyramine (Questran)
-Colsevelem (Welchol)
-Colestipol (Colestid)

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15
Q

Cholestyramine brand

A

Questran

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16
Q

Colsevelem brand

A

Welchol

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17
Q

Colestipol brand

A

Colestid

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18
Q

Fibrates

A

-Fenofibrate (Tricor)
-Gemfibrozil (Lopid)

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19
Q

Fenofibrate brand

A

Tricor

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20
Q

Gemfibrozil brand

21
Q

Omega-3 fatty acids

A

-Omega-3 fatty acid (Lovaza)
-Icosapent ethyl (Vascepa)

22
Q

Omega-3 FA brand

23
Q

Icosapent ethyl brand

24
Q

Niacin brand

25
Better for TG level
-fibrates -omega 3
26
Statin considerations
-well tolerated -obtain LFTs at baseline -muscle toxicity -darker urine -avoid grapefruit juice -NOT IN PREGNANCY -maybe hyperglycemia
27
Statin adverse effects risk factors
-renal/hepatic impairment -statin intolerance -muscle disorders -unexplained ALT elevations -other drugs -over 75 years old
28
Statin contraindications
-acute liver disease -unexplained persistnat elevation of serum transaminases -pregnancy -breastfeeding
29
Statins and muscle injury
-myalgias -myositis -rhabdomylosis
30
Statin monitoring
-obtain LFT at baseline -repeat LFT when indicated -dc if over 3x normal limit -FLP at baseline -4-12 weeks later -every 3-12 months
31
Simvastatin interactions
-conazoles -mycins -gemfibrozil ->10mg w verapamil and diltiazem ->20mg amiodarone, amlodipine, ranolazine
32
Bile Acid Resins adverse effects
-inc TG -take other meds 1 before or 4 hours after -GI effects -dec fat-soluble vitamin absorption -hypernatremia -hyperchloremia -GI obstruction
33
cholestyramine (BAR) contraindications
-complete biliary obstruction
34
Colesevelam (BAR) contraindications
-hx bowel obstruction -serum TG > 500 -hx hyperTG-induced pancreatitis
35
BARs interactions
-acetaminophen -TZDs -contraceptives -corticosteroids -ezetimbibe -fibrates -thiazide diuretics -warfarin -digoxin
36
Niacin considerations
-OTC not as regulated -some sustained release forms associated w hepatotoxicity -flushing and itching from prostaglandins
37
Niacin (Niacor) flushing
-admin ASA 30min before niacin -take close to meal -avoid alc and hot drinks -start lower dose and titrate
38
Niacin adverse effects
-flushing -inc LFTs -hyperuricemia and hyperglycemia -may inc statin levels
39
Niacin contraindications
-hepatic disease -liver transaminase elevations -peptic ulcer -arterial hemorrhage
40
Ezetimibe (zetia)
-combo w simvastatin
41
ezetimibe adverse effects
-fatigue -diarrhea -GI upset
42
Ezetimibe contraindications
-w statin and hepatic disease/elevated transaminase -pregnancy -breastfeeding -all w statin
43
Fibrates adverse effects
-GI -rash -myalgia -dizziness
44
Fibrate contraindications
-history of gallbladder disease -ESRD or dialysis -liver disease
45
Fibrates inc levels of
-statins -ezetimibe -sulfonylureas -warfarin
46
PSCK9 moa
-inj -use in heterozygous hypercholesteroemia or artherosclertotic CVD
47
PSCK9 side effects
-GI -inc LFTs -myalgia -flu -site pain
48
PCSK9 used for
-ASCVD reduction in stable ASCVD -very high risk or statin intolerant -if LDL over 190 after max statin + ezetimibe
49

Therapeutics II (55 decks)

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