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Therapeutics II > Dyslipidemia drugs (Lab) > Flashcards

Dyslipidemia drugs (Lab) Flashcards

1
Q

Atorvastatin brand name

A

Lipitor

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2
Q

Rosuvastatin brand name

A

Crestor

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3
Q

Simvastatin brand

A

Zocor

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4
Q

Pravastatin brand

A

Pravachol

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5
Q

Lovastatin brand

A

-Altoprev
-Mevacor

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6
Q

Pitavastatin brand

A

Livalo

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7
Q

Fluvastatin brand

A

Lescol

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8
Q

Statins

A
  • -Atorvastatin (Lipitor)
    -Rosuvastatin (Crestor)
    -Simvastatin (Zocor)
    -Pravastatin (Pravachol)
    -Lovastatin (Altoprev, Mevacor)
    -Pitavastatin (Livalo)
    -Fluvastatin (Lescol)
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9
Q

Cholesterol absorption inhibitors

A

-ezetimibe (Zetia)

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10
Q

Ezetimibe brand

A

Zetia

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11
Q

PSCK-9 inhibitors

A

EvolocuMAB (Repatha)
AlirocuMAB (Praluent)

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12
Q

Evolocumab brand

A

Repatha

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13
Q

Alicorumab brand

A

Praluent

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14
Q

Bile aCid sequestrants

A

-Cholestyramine (Questran)
-Colsevelem (Welchol)
-Colestipol (Colestid)

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15
Q

Cholestyramine brand

A

Questran

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16
Q

Colsevelem brand

A

Welchol

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17
Q

Colestipol brand

A

Colestid

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18
Q

Fibrates

A

-Fenofibrate (Tricor)
-Gemfibrozil (Lopid)

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19
Q

Fenofibrate brand

A

Tricor

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20
Q

Gemfibrozil brand

A

Lopid

21
Q

Omega-3 fatty acids

A

-Omega-3 fatty acid (Lovaza)
-Icosapent ethyl (Vascepa)

22
Q

Omega-3 FA brand

A

Lovaza

23
Q

Icosapent ethyl brand

A

Vascepa

24
Q

Niacin brand

A

Niacor

25
Q

Better for TG level

A

-fibrates
-omega 3

26
Q

Statin considerations

A

-well tolerated
-obtain LFTs at baseline
-muscle toxicity
-darker urine
-avoid grapefruit juice
-NOT IN PREGNANCY
-maybe hyperglycemia

27
Q

Statin adverse effects risk factors

A

-renal/hepatic impairment
-statin intolerance
-muscle disorders
-unexplained ALT elevations
-other drugs
-over 75 years old

28
Q

Statin contraindications

A

-acute liver disease
-unexplained persistnat elevation of serum transaminases
-pregnancy
-breastfeeding

29
Q

Statins and muscle injury

A

-myalgias
-myositis
-rhabdomylosis

30
Q

Statin monitoring

A

-obtain LFT at baseline
-repeat LFT when indicated
-dc if over 3x normal limit

-FLP at baseline
-4-12 weeks later
-every 3-12 months

31
Q

Simvastatin interactions

A

-conazoles
-mycins
-gemfibrozil
->10mg w verapamil and diltiazem
->20mg amiodarone, amlodipine, ranolazine

32
Q

Bile Acid Resins adverse effects

A

-inc TG
-take other meds 1 before or 4 hours after
-GI effects
-dec fat-soluble vitamin absorption
-hypernatremia
-hyperchloremia
-GI obstruction

33
Q

cholestyramine (BAR) contraindications

A

-complete biliary obstruction

34
Q

Colesevelam (BAR) contraindications

A

-hx bowel obstruction
-serum TG > 500
-hx hyperTG-induced pancreatitis

35
Q

BARs interactions

A

-acetaminophen
-TZDs
-contraceptives
-corticosteroids
-ezetimbibe
-fibrates
-thiazide diuretics
-warfarin
-digoxin

36
Q

Niacin considerations

A

-OTC not as regulated
-some sustained release forms associated w hepatotoxicity
-flushing and itching from prostaglandins

37
Q

Niacin (Niacor) flushing

A

-admin ASA 30min before niacin
-take close to meal
-avoid alc and hot drinks
-start lower dose and titrate

38
Q

Niacin adverse effects

A

-flushing
-inc LFTs
-hyperuricemia and hyperglycemia
-may inc statin levels

39
Q

Niacin contraindications

A

-hepatic disease
-liver transaminase elevations
-peptic ulcer
-arterial hemorrhage

40
Q

Ezetimibe (zetia)

A

-combo w simvastatin

41
Q

ezetimibe adverse effects

A

-fatigue
-diarrhea
-GI upset

42
Q

Ezetimibe contraindications

A

-w statin and hepatic disease/elevated transaminase
-pregnancy
-breastfeeding

-all w statin

43
Q

Fibrates adverse effects

A

-GI
-rash
-myalgia
-dizziness

44
Q

Fibrate contraindications

A

-history of gallbladder disease
-ESRD or dialysis
-liver disease

45
Q

Fibrates inc levels of

A

-statins
-ezetimibe
-sulfonylureas
-warfarin

46
Q

PSCK9 moa

A

-inj
-use in heterozygous hypercholesteroemia or artherosclertotic CVD

47
Q

PSCK9 side effects

A

-GI
-inc LFTs
-myalgia
-flu
-site pain

48
Q

PCSK9 used for

A

-ASCVD reduction in stable ASCVD
-very high risk or statin intolerant
-if LDL over 190 after max statin + ezetimibe

49
Q
A

Therapeutics II (55 decks)

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