Exam 3: Lecture 8 Flashcards

1
Q

Primary Osteoarthritis

A

Cause is unknown.

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2
Q

Osteoarthritis

A

Likely initiated by mechanical forces and leads to increased breakdown of cartilage

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3
Q

Secondary Osteo

A

Micro injury to bone

Decreased in chondrocytes repair abilities

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4
Q

Why is OA not considered an inflammatory disease

A

Mild swelling but not main component of disease

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5
Q

Clinical representation of OA

A

Degenerative and onset of 40
symptoms pain, stiffness and swelling
Slowly progressive

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6
Q

OA affects which joints?

A
Cervical or lumbar spine
CMP 
PIP
DIP
Hip 
Knee
Subtalar joint
1st metarsophalengeal
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7
Q

Joints that are uncommon for RA to affect

A

shoulder, wrist, elbow

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8
Q

Herberden’s nodes

A

size of peas and on dip’s

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9
Q

Bouchards nodes

A

develop on pip and often enlarge joints

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10
Q

OA vs. RA

A

OA: non systemic, noninflammory, and localized pathology
RA: systemic, inflammatory that involves multiple joints and possible organs

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11
Q

Classification of RA

A

Class 1: normal
Class 2:
Class 3:
Class 4: limited ability

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12
Q

Classification of Progressive RA

A

Stage 1: no presentation of x-ray
Stage 2: slight changes, no joint deformity
Stage 3: joint deformity
Stage 4: joints fused

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13
Q

Example of some inflammatory dieseases

A

RA
SLE- lupus
Scleroderma
Vasculitis

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14
Q

Some RA variants

A

Felty syndrome

Still disease: juvenile, fever

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15
Q

Management

A

through multi-disciplinary approach.

Medications

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16
Q

Group 1 of Meds

A

Non steroidal anti-inflammatory drugs (NSAID)

ex. ibuprofen

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17
Q

Group 2 of Meds

A

anti-rheumatic drugs- slow or halt progression of disease

ex. gold compounds

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18
Q

Group 3 of Meds

A

Cortico-steriods- relieve inflammation

ex. cortisone

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19
Q

Group 4 Meds

A

Biological response modifiers- inhibit progression and relieve symptoms
ex. enbrel and remicade

20
Q

Non-drug approaches

A

Natural treatments
Remedies
Gluten

21
Q

Exercise Interventions for OA

A

decrease pain and inflammation,

performance in functional tasks

22
Q

Interventions for RA

A

same as OA plus taught to recognize symptoms, and modify activity

23
Q

Spondyloarthropathies

A

AS
Reactive arthritis
juvenile spondyloarthropathy

24
Q

Ankylosing Spondylitis

A

3 criterias
low back pain for longer 3 months
limitation of motion in lumbar spine
inflammation of eyes or compression of spinal cord ie. affects bowels

25
Q

AS

A

chronic inflammatory diesase
Young adults 20-30
association with antigen HLA-B27

26
Q

Treatment for AS

A

reduce inflammatory
Mackenzie exercises
focus on extension and reduce flexion

27
Q

Uveitis

A

inflammation of uveal tract
pain and redness
visual loss or changes such as ‘floaters’

28
Q

Non-inflammatory diesease

A

fibromyalgia

Chronic fatigue

29
Q

Fibromyalgia

A

muscular pain throughout body, classic tender spots
More likely in women
Emotional, physical trauma trigger

30
Q

Symptoms and criteria

A

fatigue, headaches, joint discomfort, muscle spasms.

wide spread pain for 3 months and 11/18 tender points

31
Q

Treatment for fibromyalgia

A

light aerobic exercises, stretching, improved sleep

focus on core and neck

32
Q

Chronic fatigue syndrome

A

unknown cause, sleep doesnt help this. Commonly 30-50
headaches, flu- like feeling and low grade fever.
Anti-depressants used to treat

33
Q

Reactive arthritis

A

bacteria infection and peripheral arthritis with diarrhea

34
Q

local enthesopathy

A

inflammation of tendinous insertion to bone

Ulcers and roughened thickened skin

35
Q

Psoriatic

A

effect on DIP- swelling and deformity

related to scrolititis

36
Q

Gout

A

deposition of uric acid crystals in joints.

could be due to alcohol abuse, obesity, age etc

37
Q

Lupus

A

systematic, fever, fatigue, weight loss.

present in young women with redness of skin, enlarged liver/ spleen and easily bruised

38
Q

Scleroderma

A

disease that affects skin. Collagen disorder.

clinical features- skin ulcers, hands and mouse face

39
Q

What is the first symptom of scleroderma

A

hand swelling

40
Q

Vasulitides

A

inflammation of blood vessels
Large areas of bruising
fever

41
Q

treatments of vasulitides

A

blood transfusions and meds

42
Q

Takaysu’s

A

pulseless disease affects 4-64 and 80% female

43
Q

Gaint cell

A

primary vessels in temporal region

44
Q

Sign of positive RA factor

A

HLA B27

45
Q

AS presents first on which joint/

A

Sacral- iliac joint