Exam 3: Lecture 8 Flashcards
Primary Osteoarthritis
Cause is unknown.
Osteoarthritis
Likely initiated by mechanical forces and leads to increased breakdown of cartilage
Secondary Osteo
Micro injury to bone
Decreased in chondrocytes repair abilities
Why is OA not considered an inflammatory disease
Mild swelling but not main component of disease
Clinical representation of OA
Degenerative and onset of 40
symptoms pain, stiffness and swelling
Slowly progressive
OA affects which joints?
Cervical or lumbar spine CMP PIP DIP Hip Knee Subtalar joint 1st metarsophalengeal
Joints that are uncommon for RA to affect
shoulder, wrist, elbow
Herberden’s nodes
size of peas and on dip’s
Bouchards nodes
develop on pip and often enlarge joints
OA vs. RA
OA: non systemic, noninflammory, and localized pathology
RA: systemic, inflammatory that involves multiple joints and possible organs
Classification of RA
Class 1: normal
Class 2:
Class 3:
Class 4: limited ability
Classification of Progressive RA
Stage 1: no presentation of x-ray
Stage 2: slight changes, no joint deformity
Stage 3: joint deformity
Stage 4: joints fused
Example of some inflammatory dieseases
RA
SLE- lupus
Scleroderma
Vasculitis
Some RA variants
Felty syndrome
Still disease: juvenile, fever
Management
through multi-disciplinary approach.
Medications
Group 1 of Meds
Non steroidal anti-inflammatory drugs (NSAID)
ex. ibuprofen
Group 2 of Meds
anti-rheumatic drugs- slow or halt progression of disease
ex. gold compounds
Group 3 of Meds
Cortico-steriods- relieve inflammation
ex. cortisone