Exam 2: WBC Malignancies

Question 1

Leukemia

Answer 1

tumor is originally a leukocyte, present in blood and bone marrow

Question 2

Lymphoma

Answer 2

tumor is originally in the lymph nose, present in lymph tissue

Question 3

Acute Myeloid Leukemia

Answer 3

adults, blasts in bone marrow, malignancy of granulocytes

Question 4

Chronic Myeloid Leukemia

Answer 4

adults, mutation in Philadelphia Chromosome, usually granulocytes affected

Question 5

Acute Lymphoid Leukemia/ Lymphoma

Answer 5

children, anemia, neutropenia, thrombocytopenia, bone pain, bleeding, fever, infection, B cell malignancy, 5 year survival

Question 6

Chronic Lymphoid Leukemia/ Lymphoma

Answer 6

Mostly B cell malignancy, older adults, asymptomatic for years, fatigue, weight loss, anorexia

Question 7

Multiple Myeloma (Plasma Cell Myeloma)

Answer 7

malignant antibody secreting B cells, older adults, lower back pain, fever, night sweats, kidney dysfunction, Bence - Jones Proteins

Question 8

Hodgkin’s Lymphoma

Answer 8

Reed - Sternberg cells (RS cells), slow, more predictable progression, malignant B cells

Question 9

Non-Hodgkin’s Lymphoma

Answer 9

No RS cells, less predictable progression, malignant B cells, T cells, and NK cells

Question 10

What do lymphoid stem cells create?

Answer 10

NK cells, B cells, T cells

Question 11

What do myeloid stem cell create?

Answer 11

Neutrophils, monocyte, RBC, megakaryocytes

Question 12

What are the clinical presentations of a WBC malignancy?

Answer 12

fever, weight loss, fatigue, night sweats, bone pain, bleeding, enlargement of the spleen, changes in blood labs