Exam 2: Pharmacokinetics Flashcards
Pharmacokinetics describes:
How drugs move throughout and out of the body
In relation to Pharmacokinetics, ADM(B)E stands for?
Absorption, Distribution, Metabolism/Bioavailability, and Elimination
What does Absorption outline?
The movement of the drug from where it was administered to the bloodstream
What factors determine or influence absorption?
The dosage, lipid solubility, and the route the drug was administered
What are the 5 routes of Administration for a drug
Oral
Transdermal
Injection
Inhalation
Mucosal Membranes
Which of the 5 routes of administration is the most common?
Oral Route
Which of the 5 route of aministration is the longest lasting but the slowest to absorb?
Transdermal
Rapid Absorption with high peak blood levels?
Injection route of administration
What does the D stand for in ADME? What does it outline?
Distribution outlines the process of the drug getting from the bloodstream to the site of action
The ability of a drug to get to its site of action describes:
Bioavailability
Psychoactive drugs are reliant and dependent on what in order to exert their effects?
Passing the blood-brain barrier
Metabolism/Biotransformation describes:
How a drug is broken down in the body and turned into metabolites
Describe the action of a drug that has a “First Pass Metabolism”
- The drug is absorbed in the gut and then
- Directly to the liver via the hepatic circulation and finally
- into the bloodstream
What is a Prodrug?
A drug that only becomes active once it has been metabolized in the liver
What is the elimination of a drug?
How the drug gets our of your system or out of your body
