Exam 2: Lec 4

Question 1

Gastrointestinal zygomycosis

Answer 1

• High risk: malnourished infants or children, leukemia/ lymphoma
• Lesions in stomach, colon, ileum
• Death from bowel infarction, sepsis, hemorrhagic shock

Question 2

Cutaneous zygomycosis

Answer 2

• High risk: Burn, trama, surgery
• Burn patients, spread to underlying tissue, necrosis
• Does not often develope into disseminated disease
• Fatality rate 16%

Question 3

Disseminated zygomycosis

Answer 3

• Most common neutropenic patients w/ pulmonary infection
• Common site of infection: brain
• Abscess formation, infarction
• Fatality rate 100%
• CSF examination = normal

Question 4

Aspergillosis: without tissue invasion

Otomycosis

Answer 4

(Ear)
- Inflammation, scaling, partial deafness, trama
- Secondary to bacterial infections, following treatment

Question 5

Aspergillus fumigatus

Answer 5

• Velvety, white then green
• Reverse white to tan
• Single phialides, upper half of vesicle
• Grows at 45℃

Question 6

Aspergillus flavus

Answer 6

• Velvety, yellow to green or brown
• Reverse goldish to red brown
• Single and double phialides, entire vesicle - point in all directions

Question 7

Aspergillus niger

Answer 7

• Wooly, white to yellow then dark brown to black
• Reverse white to yellow
• Double phialides, cover entire vesicle “radiate” head
• Hyaline, septate

Question 8

Penicilliosis

Answer 8

• Pulmonary infection - Bronchiectasis airway damage
• Keratitis, allergy and hypersensitivity
• Rapid growth 4 days, greenish blue with white edges
• Branched or unbranched conidiophores - bear metula
• Metulae - part of conidiophore, supports philaide
• Phialides
• Conidia: in chains “Paintbrush or skeleton hand”

Question 9

Penicillium sp

Answer 9

• Greenish blue with white edges
• Rapid growth 4 days
• “Skeleton hand” Paint brush”

Question 10

Not saprophytic

Pneumocystis jirovecii

Answer 10

• Sexual phase:
• “Crushed ping pong balls”

Question 11

Opportunistic Saprophytic Fungal infection

Mycotic Keratitis

Answer 11

• Infection of Cornea
• White, cream colored infiltrate
• Many fungal causes Fusarium sp is most common species to cause

Question 12

Mycotic Keratitis

Fusarium sp

Answer 12

• Tapering phiialides
• Wooly white with pink to lavender