Exam 2 Flashcards
HPG
Hypothalamus
(anterior) pituitary
gonads
HPT
Hypothalamus
(anterior) pituitary
thyroid
In females LH does what
causes ovulation
In females FSH does what
controls the menstrual cycle
initiates follicle growth
In males LH does what
development of testosterone
In males FSH does what
sperm cell genesis
Half life of a hormone
the time required for its concentration to decrease to half of its initial concentration
Half life is inversely related to
metabolic clearance rate
PDE
phosphodiesterase
ends the 2nd messenger system by dephosphorylating the enzyme
Afferent
away from the tissue
Efferent
towards the tissue
Three main examples for Afferent vs. Efferent
Blood vessels
Lymph vessels
Nerves
Types of cell communication
Endocrine
Autocrine
Paracrine
Juxtracrine
Intracrine
Endocrine cell communication
target sites are on distant cells
Autocrine cell communication
signal is released outside of the cell and acts on itself
Paracrine cell communication
target sites are on adjacent cells, rapid breakdown of ligand helps prevent distant effects
Juxtracrine cell communication
ligand on signaling cell binds target cell receptors
Intracrine cell communication
signal is released within the cell and acts within the cell
Organs involved in the endocrine system
Pineal gland
pituitary gland
thyroid
adrenal gland
pancreas
uterus/ovaries in female
testes in male
Posterior pituitary hormones
ADH
Oxytocin
ADH is released by the _____, targets the _____, and effects ______.
released by the hypothalamus
stored in the posterior pituitary
targets the kidneys, sweat glands, circulatory system
Effects water balance
Oxytocin (OT) is made by the ______, targets the ______, and effects _______
made by the posterior pituitary
targets the female reproductive system
effects- triggers uterine contractions during childbirth
Anterior pituitary hormones
LH-luteinizing hormone
FSH-follicle stimulating hormone
TSH- Thyroid stimulating hormone
PRL-Prolactin
GH-growth hormone
ACTH-adrenocorticotropic hormone
Luteinizing hormone is released by _______, released from the _______, targets the _______, and effects _____
Released by GnRH
Released from the anterior pituitary
targets the reproductive system
stimulates production of sex hormones by the gonads
Follicle Stimulating hormone is released by _____, released from _____, targets ______, and effects _____
released by GnRH
released from the anterior pituitary
targets the reproductive system
effect- stimulates production of sperm and eggs
Thyroid Stimulating hormone is released by _____, released from the _____, targets _____, and effects ______
released by Thyroid Releasing Hormone
released from the anterior pituitary
targets the thyroid gland
effect- stimulates the release of thyroid hormone which regulates metabolism
Prolactin is released by _____, released from _____, targets ______, and effects ______
released by Prolactin releasing hormone (inhibited by Parathyroid inhibiting hormone)
released from the anterior pituitary
targets the mammary glands
effect- promotes milk production
Growth hormone is released by ______, released from _____, targets _____, and effects ______
released by growth hormone releasing hormone (inhibited by Growth hormone inhibiting hormone)
released from the anterior pituitary
targets the liver, bone, muscle
effect- induces targets to produce Insulin-like growth factors (IGFs) which then stimulates body growth and a higher metabolic rate
ACTH is released by _____, released from _____, targets _____, and effects _____
released by CRH (corticotropin releasing hormone)
released from the anterior pituitary
targets the adrenal glands
effect- induces targets to produce glucocorticoids, which regulate metabolism and the stress response
Tissue types in the pituitary
PD-pars distalis- anterior
PN-pars nervosa- posterior
PI- pars intermedia- intermediate
Anterior pituitary cell types
acidophils
basophils
chromophobes
Acidophils do what
protein hormones
GH, PRL
Basophils do what
glycoprotein hormones
ACTH, TSH, FSH, LH
Chromophobes are
support cells
The hypothalamus releases growth hormone-releasing hormone that stimulates
the anterior pituitary to release growth hormone
The release of growth hormone
stimulates adipose cells to break down stored fat, fueling growth effects
increases uptake of amino acids from blood and enhances cellular proliferation and reduces apoptosis
stimulates liver to break down glycogen into glucose, fueling growth effects
When the liver is stimulated by GH it does what
breaks down glycogen into glucose
releases IFG-1 which stimulates growth effects further
High IGF-1 levels are perceived by the _______ and cause _______
hypothalamus
cause GHIH release to inhibit GH in the anterior pituitary
slows growth effects
ADH does what
regulates blood pressure
Hormone regulation techniques
feedback loops
half life and clearance rates
source
targets (receptors)
Galactorrhea
abnormal or prolonged lactation/overgrowth of the cells that produce prolactin
Cushing’s Syndrome
too much cortisol (glucocorticoid)
pituitary tumor overproduces ACTH
Growth Hormone Problems
hyposomatotropinism
hypersomatotropinism
caused by trauma or a tumor
Hyposomatotropinism
not enough growth hormone
dwarfism
Hypersomatotropinism
too much growth hormone
In adults it leads to acromegaly
In children it leads to gigantism
Polyuria
produces abnormally high volumes of dilute urine
Polydipsia
excessive thirst
Hyponatremia
low Na+ blood retention
Hypernatremia
High Na+ in the blood
Hyponatremia results from
excessive urine
Hypernatremia results from
extreme thirst
Diabetes insipidus four types
Central
nephrogenic
dipsogenic
gestational
Diabetes insipidus- Central type is caused by
lack of ADH
Diabetes insipidus- nephrogenic is caused by
ADH production is okay but kidneys don’t respond
Diabetes insipidus- dipsogenic is caused by
problem with hypothalamus makes you thirsty- drink too much
Diabetes insipidus- gestational is caused by
placenta making too much enzyme that breaks down ADH
Thyroid gland hormones
thyroxine T4
triiodothyronine T3
Calcitonin
Thyroxine T4 and triiodothyronine T3 are what class of hormone
amine
Thyroxine T4 and triiodothyronine effect
stimulate basal metabolic rate
Calcitonin is what class of hormone
peptide
Calcitonin effects
reduces blood Ca2+ levels
Hypothyroidism
levels of thyroid hormone are low
gland can be small or large (goiter)
weight gain, tiredness, cold
Iodine deficiency
Hyperthyroidism
levels of thyroid hormone are high
high energy levels, skinny, overheat easy
Thyroid Hormone synthesis
- inorganic iodide is transported into the gland
- intrathyroidal iodide is oxidized to iodine under the influence of H2O2 and peroxidase
- iodine is bound in thyroglobulin to tyrosine, forming monoiodotryrosine and diiodotyrosine
- the iodotyrosines are enzymatically coupled to form thyroxine and triiodothyronine
- iodothyronines, T4 and T3, are stored in thyroglobulin until released into circulation
- the unused iodotyrosines are deiodinated and the iodide is recycled
parathyroid hormone is the opposite of
calcitonin
Parathyroid hormone effects
increases blood calcium levels when they are low
Adrenal gland regions
medulla- middle
cortex- outer
Adrenal cortex zones
Zona reticularis- inner
Zona fasciculata- middle
Zona glomerulosa- outer
The Zona reticularis secretes what hormone
mineralcorticoids
Aldosterone
Zona fasciculata secretes
glucocorticoids
cortisol
corticosterone
cortisone
Zona glomerulosa secretes
Gonadocorticoids
Hormones of the Adrenal glands
Aldosterone
Cortisol, corticosterone, cortisone
epinephrine/norepinephrine
Aldosterone is what class of hormone
steroid
Aldosterone effect
increases blood Na+ levles
Cortisol, corticosterone, cortisone hormone class
steroid
cortisol, corticosterone, cortisone effect
increases blood glucose leveles
Epinephrine, norepinephrine hormone class
amine
Epinephrine, norepinephrine effect
stimulates fight or flight response
3 plasma proteins that are found bound to thyroid hormone
thyroxine
transthyretin
albumin
Parathyroid glands have what type of receptors
calcium sensing that mobilize intracellular calcium in response to activation
Two cell types in the parathyroid
oxyphil cells- function unknown thought to be retired chief cells
Chief cells- make/secrete parathyroid hormone
Parathyroid hormone does what
stimulates osteoclasts, inhibits osteoblasts
stimulates reabsorption int kidney
stimulates calcitriol in the kidneys
thyroid hormone function
regulation of basal metabolic rate
protein synthesis
normal fetal and childhood development
interact with repro hormones
increase sensitivity to catecholamines
Pineal gland function
light induced activation of suprachiasmatic nucleus
which prevents melatonin secretion from the pinacocytes
Pinacocytes create
melatonin
Reproductive hormones of the testes
testosterone
Inhibin
Testosterone is what class of hormone
steroid
testosterone effect on testes
stimulates development of male secondary sex characteristics and sperm production
inhibin hormone class
protein
inhibin effect on testes
inhibits FSH release from the pituitary
hormones of the ovaries
estrogens and progesterones
Estrogens and progesterones hormone class
steroid
estrogens and progesterones effect on the ovaries
stimulates development of female secondary sex characteristics and prepare body for childbirth
hormone of the placenta
human chorionic gonadotropin
human chorionic gonadotropin hormone class
protein
human chorionic gonadotropin effect on placenta
promotes progesterone synthesis during pregnancy and inhibits immune response against the fetus
Length of the estrus cycle in cattle
21 days
What happens in the luteal phase of the estrus cycle
Under the influence of progesterone
day 1-17
ovulation marks the beginning of this phase
group of follicles are recruited and grown in response to FSH
One follicle becomes dominant and matures in to an ovum
LH causes the cells on the ovary that made up the follicle differentiate and make a Corpus luteum
CL makes progesterone which inhibits LH and FSH and prevents ovulation
If not pregnant prostaglandin lyses the luteal tissue and causes regression
Follicular phase of the estrus cycle
begins with the removal of progesterone which allows for GnRH pulses
Results in more FSH and LH production which supports follicular development
The dominant follicle produces increasing amounts of estrogen that once it reaches threshold, a surge of LH results in ovulation
How is vitamin D made
a precursor gets converted in the skin by UV, then modified in the liver, and modified again in the kidney to the active form
General Adaptation syndrome GAS is
responses to stress- 3 stages
3 stages of GAS
- alarm reaction-fight or flight-short term
- resistance-adapt metabolism
- exhaustion-depression, immune suppression, weight gain
RAAS (renin-angiotensin-aldosterone system)
Blood pressure falls
kidneys release renin
renin splits angiotensinogen (made in liver) into pieces- angiotensin I
Angiotensin is inactive and flows through the blood, split by ACE in lungs and kidneys to make angiotensin II which is active
angiotensin II causes arterioles to constrict- increasing blood pressure and triggering adrenal glands to release aldosterone to pituitary and ADH
Aldosterone and ADH cause kidneys to retain sodium which increases sodium and causes water retention
Endocrine pancreas synthesizes and secretes hormones into the
blood
Where the cell types in the endocrine pancreas reside
islets of langerhans
Cell types in the Islets of langerhan
alpha, beta, delta, PP cells
which make glucagon, insulin, somatostatin, and pancreatic polypeptide