EX 3 Flashcards
- provides a measure of the total amount of minerals within a sample
- furnishes a basis for judging the identity and cleanliness of a drug
- gives information relative to its adulteration with inorganic matter
ASH CONTENT
Used to determine quality and purity of crude drug
ASH CONTENT DETERMINATION
contains inorganic radicals like phosphates, carbonates and silicates of sodium, potassium, magnesium, calcium
ASH
carbon and organic matter present in the drug is converted to ash at a temperature of 450º C. It mostly contains carbonates, phosphates, silicates and silica.
TOTAL ASH
carbon and organic matter present in the drug is converted to ash at a temperature of ____º C
450C
Total ash may be treated with 2N HCl, which removes many inorganic salts to yield mainly silica in the residue of ____
ACID INSOLUBLE ASH
Total ash may be treated with ____, which removes many inorganic salts to yield mainly silica in the residue of acid insoluble ash.
2N HCl
is produced by separating the water-soluble material from the total ash. In this case most of the water-insoluble salts that may contribute in total ash are removed to find water-soluble ash content acid-insoluble
WATER SOLUBLE ASH
used to contain compounds when heated to extremely high temperatures
CRUCIBLE & COVER
satisfies high-temperature requirements up to 1050°C (1922°F)
QUARTZ CRUCIBLE & COVER
Quartz crucible and cover can withtstand the temperature up to
1050C (1922F)
used to grasp a hot crucible or evaporating dishes
CRUCIBLE TONGS
the most important analytical factor to be regulated in making ash determinations
CONTROL OF TEMPERATURE
the ash consists largely of ____ formed from Ca(C₂HO₄)₂ contained in the drug
CaCO₃
the ash consists largely of CaCO₃ formed from ____ contained in the drug
Ca(C₂HO₄)₂
calcium oxalate
when incineration is carried out as a:
dull red heat – Ca(C₂HO₄)₂ is converted to ____
CaCO₃
when incineration is carried out as a:
bright red heat – varying amounts of the CaCO₃ are converted to the ____ with consequent variable results
CaO
when incineration is carried out as a:
Ca(C₂HO₄)₂ is converted to CaCO₃
dull red heat
when incineration is carried out as a:
varying amounts of the CaCO₃ are converted to the CaO with consequent variable results
bright red heat
METHODS OF ASH CONTENT DETERMINATION
Direct incineration
Muffle furnace
LAB PROCEDURE
set the muffle furnace into ____ then start incinerating the plant samples for 5-6 hours
550C
LAB PROCEDURE
Determination of the Acid-insoluble ash:
boil the ash obtained with ____ for **5 minutes **
25mL diluted HCl
%total ash wet
g of ash / g of fresh sample x 100
