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Hematology I & II > Erythropoiesis > Flashcards

Erythropoiesis Flashcards

1
Q

stored iron

A

ferritin

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2
Q

component of hemoglobin that produces pigment and transports O2 to tissues and CO2 from tissues

A

heme

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3
Q

It is needed for for DNA synthesis and may cause megaloblastic anemia.

A

Folic acid

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4
Q

glycoprotein hormone secreted by the kdineys

(peritubular cells)

A

erythropoietin

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5
Q

first human hematopoietic growth factor to be identified

A

erythropoietin

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6
Q

initiates RBC production

A

erythropoietin

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7
Q

True or False:

Hypoxia can be detected by peritubular fibroblasts of kidney

A

True

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8
Q

transcription factor in erythrokinesis

A

Hypoxia-Inducible Factor 1

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9
Q

part of Erythroid Islands which stands as
RBC anchorage to extracellular matrix

A

fibronectin

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10
Q

How many mitotic dividions are needed for pronormoblast to become polychromatophilic normoblast?

A

2-4 mitotic divisions

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11
Q

Chronologically enumerate the developmental stages of erythropoiesis.

A
  1. Rubriblast/ Proerythroblast /Pronormoblast
  2. Prorubricyte/ Basophilic normoblast
  3. Rubricyte/ Polychromatophilic normoblast
  4. Metarubricyte/ Orthochromic normoblast
  5. Reticulocyte/ Polychromatophilic erythrocyte
  6. Mature erythrocyte/ Mature RBC
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12
Q

Identify the developmental stage.

cytoplasm: perinuclear halo, prominent Golgi bodies, no granules

A

Rubriblast

Pronormoblast

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13
Q

Identify the developmental stage.

produce proteins and enzymes for iron uptake

A

Rubriblast

Pronormoblast

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14
Q

Identify the developmental stage.

Hb synthesis occurs and large amount of mRNA

A

Prorubricyte

Basophilic normoblast

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15
Q

Identify the developmental stage.

cytoplasm has tinge of pink and its division is the last mitotic stage with 3 daughter cells

A

Rubricyte

Polychromatophilic normoblast

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16
Q

Identify the developmental stage.

Hb appears for the first time and Hb synthesis is increased

A

Rubricyte

Polychromatophilic normoblast

17
Q

Identify the developmental stage.

Its chromatin is pyknotic and tightly condensed.

Cytoplasm is acidophilic.

Enucleation occurs and vimentin is lost.

A

Metarubricyte

Orthochromic normoblast

18
Q

Identify the developmental stage.

It is the polychromatophilic erythrocyte.

A

Reticulocyte

19
Q

Identify the developmental stage.

Has a diffused reticulum and shows organelle degradation (lipoxygenase)

A

Reticulocyte

Polychromatophilic erythrocyte

20
Q

Identify the developmental stage.

Cytoplasm has biconcave disc and delivers oxygen to tissues.

A

Mature erythrocyte

Mature RBC

Hematology I & II (9 decks)

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