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Hematology I & II > Acute Leukemias > Flashcards

Acute Leukemias Flashcards

1
Q

What are the 2 types of acute leukemias?

A
  • AML: Acute Myelogenous Leukemia
  • ALL: Acute Lymphoblastic Leukemia
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2
Q

2 factors that provide porgnostic information

A
  • cytogenetic analysis
  • cell surface antigens
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3
Q

3 substances that predict an inferior outcome

A
  • CD34
  • P-glycoprotein
  • FLT3 gene
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4
Q

Classification of Anemia

  • more than 30% blasts suffice for diagnosis
A

French-American-British classification

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5
Q

Classification of Anemia

  • based on morphological characteristics of Wright-stained cell
  • based on cell type & cell maturity
A

FAB classification

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6
Q

Frech-American-British classification

AML:

ALL:

A

AML: M0-M7

ALL: L1-L3

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7
Q

Leukemia Classification

  • more than 20% blasts suffice for diagnosis
A

World Health Organization (WHO) classification

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8
Q

Leukemia Classfication

  • morphology
  • cytochemistry immunophenotype
  • genetic
  • clinical features
A

WHO classification

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9
Q

Leukemias with __(1)__ & __(2)__ are frequently characterized by an unfavorable response to therapy

A
  1. complex karyotypes
  2. partial deletions/loss of chromosomes
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10
Q

Which classification is now the standard of diagnosis?

A

WHO classification

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11
Q

AML is also known as?

A
  • *A**cute Myelogenous Leukemia or
  • *A**cute Myeloid Leukemia
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12
Q

most common leukemia subtype

A

Acute myeloid leukemia

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13
Q

Acute Myeloid Leukemia

blasts evolve from?

A

common myeloid precursors

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14
Q

AML involves genetis disruption of?
*There are two.

A
  1. FLT3 gene
  2. Core-binding factor (CBF) complex
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15
Q

Acute Myeloid Leukemia

FLT3 encodes what type of enzyme to perform leukemogenesis?

A

Type III Receptor Tyrosine Kinase

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16
Q

Acute Myeloid Leukemia

regulates hematopoiesis & normal myeloid development

A

Core-binding facyor (CBF) complex

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17
Q

constitute AML with favorable prognosis

A

t(16,16) (p13q22)

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18
Q
  • undifferentiated myeloid blasts
  • not otherwise categorized in WHO classification
  • do not fulfill criteria for inclusion
A

FAB M0

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19
Q
  • AML without maturation
  • myeloblasts and promyelocytes predominate
A

FAB M1

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20
Q

pink/red rod-shaped cytoplasmic structures

21
Q

represents fused primary granules

22
Q

AML with acquired pseudo-Pelger-Huet anomaly

23
Q

Which AMLs have auer rods?

A
  • FAB M1
  • FAB M2
  • FAB M3
24
Q
  • AML with maturation
  • t(8;21)
25
Acute Promyelocytic Leukemia
FAB M3
26
most aggressive of acute leukemias with a severe bleeding tendency
FAB M3
27
cell with mass or bundles of Auer rods
Faggot cells
28
contains Faggot cells
FAB M3
29
* t(15;17) * increased incidence of **d**isseminated **i**ntravascular **c**oagulation (DIC)
FAB M3
30
Acute Myelomonocytic Leukemia
FAB M4
31
FAB M4/Acute Myelomonocytic Leukemia is also known as?
Naegeli's Type of Monocytic Leukemia
32
variant of FABM4
FAB M4Eo
33
BM aspiration reveals myeloblasts & monoblasts with **abnormal eosinophils**
FAB M4Eo
34
inversion of chromosome 16
inv (16)
35
inv(16) is laso known as
t(16;16)
36
most cells are monocytic
FAB M5
37
FAB M5a is also known as *\*There are two.*
* Acute Monoblastic Leukemia * Schilling's type of Acute Leukemia
38
large monoblasts ≥ 80% in the bone marrow and peripheral blood
Acute Monoblastic Leukemia
39
Acuye Monocytic Leukemia
FAB M5b
40
* t(8;16) * monoblasts, promonocytes, monocytes
FAB M5b
41
blasts frequently have a muddy or smoggy gray-blue cytoplasm
FAB M5
42
FAB M6 is also known as? *\*There are three.*
* Acute Erythroleukemia * Di Guglielmo Syndrome * Erythemic Myelosis
43
\> 50% erythroblasts (orthochromatic normoblasts)
FAB M6
44
Acute Megakaryoblastic Leukemia
FAB M7
45
50% or more of the blasts are of megakaryocytic lineage
FAB M7
46
Immunophenotyping reveals that megakaryoblasts express one or more of the platelet glycoproteins which are?
CD41 or CD61
47
t(1;22)(p13;q13)
FAB M7
48
3 monocytic lineage
1. CD14 2. CD11b 3. CD11c
49
Erythroblasts consist of?
* glycophorin A * Hb A

Hematology I & II (9 decks)

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