Erectile Dysfunction

Question 1

Background information for Phosphodiesterase-5 Inhibitors (PDE-5 Inhibitors)

Answer 1

A common cause of erectile dysfunction is insufficient blood flow to the penis

Question 2

Pharmacology of Phosphodiesterase-5 Inhibitors (PDE-5 Inhibitors)

Answer 2

Prolong the activity of nitric oxide by blocking the enzyme, PDE-5, which deactivates nitric oxide. Nitric oxide is a potent vasodilator so it expands blood vessels and increases blood flow

Question 3

Indications of Phosphodiesterase-5 Inhibitors (PDE-5 Inhibitors)

Answer 3

• Erectile Dysfunction

Question 4

Side effects of Phosphodiesterase-5 Inhibitors (PDE-5 Inhibitors)

Answer 4

• Headache
• Hypotension
• Priapism (persistent erection)

Question 5

Drug interactions of Phosphodiesterase-5 Inhibitors (PDE-5 Inhibitors)

Answer 5

• Increased risk of hypotension when used with other medications that lower bp
• Increased risk of epistaxis (nosebleed) when used with an anticoagulant or antiplatelet

Question 6

List the brand names and generic names for Phosphodiesterase-5 Inhibitors (PDE-5 Inhibitors)

Answer 6

Brand Name: Viagra, Cialis, Levitra [Staxyn]

Generic Name: Sildenafil, Tadalafil, Vardenafil

Question 7

What do Phosphodiesterase-5 Inhibitors (PDE-5 Inhibitors) medications end with?

Answer 7

“-afil”