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Pharmacy Certification > Depression > Flashcards

Depression Flashcards

1
Q

Background information for Selective Serotonin Reuptake Inhibitors (SSRIs)

A

Serotonin is a neurotransmitter that plays a key role in depression, behavior, eating, and nausea/vomiting. Serotonin must be available in the synaptic cleft long enough to exert an effect. When neurons absorb serotonin it can no longer exert an effect

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2
Q

Pharmacology of Selective Serotonin Reuptake Inhibitors (SSRIs)

A

Block the reuptake of serotonin, allowing serotonin to remain in the synaptic cleft to allow more time to exert it effects

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3
Q

Indications of Selective Serotonin Reuptake Inhibitors (SSRIs)

A
  • Depression
  • Behavior disorders
  • Eating disorders
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4
Q

Side effects of Selective Serotonin Reuptake Inhibitors (SSRIs)

A
  • Changes in body weight
  • Nausea
  • Diarrhea
  • Serotonin syndrome
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5
Q

Drug interactions of Selective Serotonin Reuptake Inhibitors (SSRIs)

A
  • Increased risk of bleeding when taken with NSAIDs, anticoagulants, or antiplatelets
  • Increased risk of serotonin syndrome when used with other medications that increase the effect of serotonin
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6
Q

Important Note

A

All antidepressants have the potential to cause suicidal ideation and behavior in young patients

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7
Q

Important Note

A

All antidepressants have a slow onset of action and may require several weeks to reach peak effect

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8
Q

List the brand names and generic names of Selective Serotonin Reuptake Inhibitors (SSRIs)

A

Brand Name: Celexa, Lexapro, Prozac, Luvox, Paxil, Zoloft

Generic Name: Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline

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9
Q

Background information for Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs)

A

Similar to serotonin, norepinephrine also plays a role in depression and behavior

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10
Q

Pharmacology of Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs)

A

SNRIs works just like SSRIs, but in addition to blocking the reuptake of serotonin, they also block the reuptake of norepinephrine

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11
Q

Indications of Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs)

A
  • Depression
  • Eating disorders
  • Anxiety disorders
  • Diabetic peripheral neuropathy
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12
Q

Side effects of Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs)

A
  • Changes in body weight
  • Nausea
  • Diarrhea
  • Serotonin syndrome
  • Cardiovascular side effects
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13
Q

Drug interactions of Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs)

A
  • Increased risk of serotonin syndrome when taken with other drugs that increase serotonin activity
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14
Q

Important note

A

All antidepressants have the potential to cause suicidal ideation and behavior in young patients

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15
Q

Important note

A

All antidepressants have a slow onset of action and may require several weeks to reach peak effect

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16
Q

List the brand names and generic names for Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs)

A

Brand Name: Pristiq, Cymbalta, Savella, Effexor

Generic Name: Desvenlafaxine, Duloxetine, Milnacipran, Venlafaxine

17
Q

Background information for Tricyclic Antidepressants (TCAs)

A

Serotonin and norepinephrine play a role in mood and energy levels

18
Q

Pharmacology of Tricyclic Antidepressants (TCAs)

A

Block the reuptake of serotonin and norepinephrine

19
Q

Indications of Tricyclic Antidepressants (TCAs)

A
  • Depression
  • Eating disorders
  • Generalized anxiety disorders
  • Diabetic peripheral neuropathy
20
Q

Side effects of Tricyclic Antidepressants (TCAs)

A
  • Tachycardia (heart beats faster than normal)
  • Heart palpitations (feeling of rapid or pounding heart)
  • Hypertension (high bp)
  • Dry mouth
  • Weight gain
  • Reduced sex drive
  • Serotonin syndrome
21
Q

Drug interactions of Tricyclic Antidepressants (TCAs)

A
  • Increased risk of serotonin syndrome when taken with other drugs that increase serotonin activity
22
Q

Important note for Tricyclic Antidepressants (TCAs)

A

TCAs are an older class of antidepressants, they generally have more side effects and drug interactions

23
Q

Important note for Tricyclic Antidepressants (TCAs)

A

All antidepressants have the potential to cause suicidal ideation and behavior in young patients

24
Q

Important note for Tricyclic Antidepressants (TCAs)

A

All antidepressants have a slow onset of action and may require several weeks to reach peak effect

25
Q

List brand names and generic names of Tricyclic Antidepressants (TCAs)

A

Brand Name: Elavil, Sinequan, Pamelor, Tofranil

Generic Name: Amitriptyline, Doxepin, Nortriptyline, Imipramine

Pharmacy Certification (28 decks)

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