Equine Sarcoids Flashcards
What are equine sarcoids
Spontaneous, locally invasive, fibroblastic skin tumors
What is the most common tumor in equine?
Sarcoids
T/F: Equine sarcoids has a high metastatic rate
FALSE- no metastasis but recurrence is common
What is the likely cause of Equine sarcoids?
Bovine papilloma virus 1 &2
What are the three types of sarcoids?
Fibroblastic
Verrucous
Occult
Which type of sarcoids appear similar in characteristic to proud flesh?
Fibroplastic
Which type of sarcoids appear warty like in appearance?
Verrucous
Which type of sarcoids appear to be slightly raised skin nodules?
Occult
What are some pathohistology characteristics of equine sarcoids?
Hyperplastic/hyperkeratotic epidermis
Marked rete-peg formation
Irregularly arranged fibroblasts (whorls)
No invasion of underlying muscle
T/F: DDx of Equine sarcoids include exuberant granulation tissue, fibrosarcoma, cutaneous habronemiasis, squamous cell carcinoma and dermatophytosis
TRUE
T/F: Equine sarcoids can spontaneously regress
TRUE
What are four extreme treatment options for equine sarcoids
Sx excision
Cryosurgery
Chemotherapy
Bacillus-Calmette-Guerinimmunotherapy (BCG)
If you use cryotherapy to treat equine sarcoids, how does the site heal?
Tissue will slough off and heal by second intention
What is the chemotherapy drug used to treat equine sarcoids?
Cisplatin w/ sesame oil
4 intratumoral injection given Q2wks
Where are two common locations for equine sarcoids?
Inguinal region or on the head
How does cryosurgery result in tissue destruction?
formation of intra- and extracellular ice crystals
Thermal shock before freezing takes place
Cell dehydration
Denaturing lipoprotein complexes in cell membranes
T/F: Cryosurgery achieves maximum lethal effects by using a fast freeze, fast thaw method
FALSE- fast freeze, slow thaw (at least twice)
T/F: Cryosurgery heals by primary intention
FALSE- 2nd intention
Forms white hairs around the area
Can take up to 8 weeks to slough
Forms a leathery scar
Give tetanus prophylaxis
T/F: BCG therapy has a specific effect on cell mediated immunity
FALSE- non-specific effect
