Epoxide formation Flashcards
1
Q
What is an Epoxide Formation?
A
An alkene (double bond) is metabolised to form an epoxide ring
2
Q
What will this NOT happen in?
A
Benzene rings - not an alkene
3
Q
What enzymes are involved?
A
CYP enzymes
4
Q
Why would an Epoxide formation occur?
A
To form a more active metabolite.
5
Q
Give an example of a drug metabolised this way:
A
Carbamazepine: antiepileptic
6
Q
If the epoxide ring was HYDROLYSED what would form and what conformation??
A
A trans conformation alcohol
