Dehalogenation Flashcards
1
Q
What happens in this reaction?
A
A halogen: Cl, Br, I, is substituted with an OH group
2
Q
What enzymes are involved?
A
CYP enzymes
3
Q
Give an example of a compound that undergos this reaction
A
Acid chloride is spontaneously converted to a a carboxylic acid by DEHALOGENATION in the body (Water in the body is enough to cause the reaction to happen)
4
Q
What can you say about an ALIPHATIC halide group?
A
Not many drugs contain them because they will break down if exposed to sunlight for too long.
5
Q
Give an example of a drug that undergoes this reaction:
A
Chloramphenicol
