Deamination (oxidative)

Question 1

What happens in this reaction?

Answer 1

An amine (NH2) group is lost from the original compound and the product formed is C=O. This is where the ‘oxidative’ term comes in: The intermediate formed in this reaction contains an OH group, which is then oxidised to form the product C=O

Question 2

What is the bi-product of this reaction?

Answer 2

Loss of an amine group: NH3

Question 3

What enzymes are involved in this reaction?

Answer 3

Amine oxidases, or CYP enzymes

Question 4

Give and example of a group of drugs that undergo this reaction

Answer 4

Amphetamines