Epithelial Glands: cytomembranes

Question 1

The Major Phopholipids of the Plasma Membrane are..

Answer 1

Phosphatidlycholine

Phosphatidylethanolamine

Phosphatidylserine

Sphingomyelin

Phosphatidylinsoitol (inner Leaflet)

Question 2

The interior of the plasma membrane is

Answer 2

hydrophobic

Question 3

The plasma membrane is made up of

Answer 3

lipids

proteins

Question 4

What do channel proteins let pass through

Answer 4

ions

ligand gated

Question 5

What to carrie proteins let pass through

Answer 5

sugars

amino acids

nucleosides

Question 6

Faccilitated diffusion

Answer 6

glucose

small ions

charged moelecules

Question 7

Secretory protein pathway

Answer 7

rer

cis golig apparatus

secretory vesicles

lumen

Question 8

The Luminal/ endoplasmic part of the ER correlates with

Answer 8

the exterior of the cell

Question 9

The protplasmic sufaces faces the

Answer 9

cytosol

Question 10

The extraceullar sufaces faces the

Answer 10

lumen

Question 11

When you spilt the plams membrane you get

Answer 11

surfaces

Question 12

KDEL

Answer 12

signal that enables you to be retained in the ER

Question 13

Trans golgi Network

Answer 13

sorting of proteins to the lysosomal or exocytosis pathway

Question 14

Faculative

Answer 14

regulated secretion

Question 15

Cargo Sorting

Answer 15

Microtubules

Actin Filaments

Question 16

Golgi Appartus Functions

Answer 16

1. modification of carbohydrates attached to glycoproteins and proteoglycans (from ER)
2. sorting of cargo to different destinations
3. sythesis of SPHINGOMYELIN

Question 17

Clathrin

Answer 17

Dynamin(pinches off)

Adaptins (stabilize clathrin coat)

Basket arrangment

recyled after transport into plasma membrane

Question 18

Clathrin Coated Vesicles

Answer 18

Trans golgi to lysosomes

External Cell to lysosomes

*Adaptin ( helps form clathrin coat on vesicle)

Question 19

COP-coated

Answer 19

Er to golgi (COP II)

Cis golgi trans to golgi network (COP I)

ARF-GTP: helps form coatmer on cytosolic side of vesicle

ARF-GDP vesicle binds to plasma membrane

Question 20

Vesicle Fusion

Answer 20

Recogntion: V-SNARE (vesicle)

+

T-SNARE (target membrane)

Fusion: NSF+SNAPS

*SNARES=SNAP RECEPTORS

Question 21

Lysosomal Storing pathway

Answer 21

Lysosomal hydrolase (made in ER)

then

Add M6P (cis golgi)

then

M6P receptor (trans golgi network)

then

by method of clathrin coated vesicle (primary lysosome)

Question 22

Endocytosis

Answer 22

Clathrin free phagosomes

Clathrin coated

pincocytosis

Question 23

Clathrin-Coated

Answer 23

small macromolecules

Question 24

Pinocytosis

Answer 24

cells dinking fluid

*caveolin*

Question 25

Clathrin free phagosomes

Answer 25

large particles

(virus, bacteria,debris)

Question 26

Receptor Mediated Endocytosis of cholestoral

Answer 26

LDL receptor/comples

clathrin

endosome

primary lysosome

secondary lysosomes

LDL receptor recyled

**Familial hypercholesterolemia (mut of LDL receptor)

**cholestoral usually insoluable

Question 27

Mitocondria

Answer 27

most mitocondria proteins encoded in cytosol ribosomes then transported into mitocondria by targeting signals

TARGET into mictocondria: TOM, Hsp 60, Hsp 70

Oxidative phosphorylation

Outer membrane(permeable) porins

Inner membrane (ETC)

Question 28

Functions of Mitocondria

Answer 28

1. apoptosis: procapsases 2,3,9

steroidgenisis

thermogensis (uncoupling) prton leak UCP-1 (BROWN FAT)

Question 29

Where do you get your mitocondrial DNA from?

Answer 29

mother

Question 30

What is MERRF

Answer 30

issue with mitocondrial dna

pt mutation of tRNA for lysine

Question 31

Peroxisomes

Answer 31

H202 catalase breaks down to H20

zwelleger syndrome

single membrane bound

liver

proteins for peroxisome made in cytopasm

Target Sequence : ser-lys-leu