Cell Signaling Flashcards
What are some examples of Neurotransmitters?
acetylcholine dopamine epinephrine (adrenaline) serotonin histamine glutamate GABA
What is the release of neurotransmitters released by?
Action Potentials
What type of channel does acetylcholine acitvate?
ligand gated
Epinephrine
has dual function
neurotransmitter and a hormone
Where is hTERT seen?
most human tumors
endless growth in cluture
Cell Signaling Molecule Types
Autocrine Endocrine Paracrine Neurotransmitter neuroendocrine
Autocrine signaling
cell responding to signals that they produce themselves
secrete prostagladins and interleukins
ex. GF (if unregulated leads to tumors)
Paracrine signaling
signals that are acting locally can bind to oen or more receptors secrete hormones and growth factors ex. neurotransmitters at synapse glucagon somatostatin
Examples of Paracrine signaling genes
fribroblast growth factor
hedgehog
wingless
transforming growth factor and super family
endocrine signaling
secrete polypeptide and steroids into blood
distant target cells
ex. neuroendocrine
Steroid hormones circulate in blood bound to what?
proteins
Steroid hormones can be adminstered
orally
steroid hormones are administered from
cholesterol
Steroid hormones are (stored/or not stored) in producing endocrine cell?
not stored
Steroid hormones bind to what type of receptors
intracellular
Are steroid hormones polar or non polar
non polar
(hydrophobic) diffuses across plasma membrane
Testosterone
estrogen
progesterone
are all examples of…
ex steroid hormones
corticosteroid is produced by
cortex of adrenal gland
There are two types of corticosteroids
glucucorticoids( stimulate production of glucose)
mineral corticoids (act on kidney to regulate water and alt balence)
What type of signaling molecules bind to intracellular receptors?
Steroids
VitaminD
Retinoids ( syn by vitamin A(
Thrroid hormone
Nitric oxide
signaling molecule
Does NO cross the plasma membrane?
Yes. but it does not bind to intracellular receptors instead it REGULATES ACTIVITY OF INTRACELLULAR TARGET ENZYMES.
what type of cell signaling is NO?
paracrine