Epilepsy Drugs

Question 1

MoA of 1st line drug for absence seizures?

Answer 1

Ethosuximide. Blocks thalamic T-type Ca channels

Question 2

MoA of first line drugs (2) for acute status epilepticus?

Answer 2

Diazepam/Lorazepam. Increase GABAa

Question 3

1st and 2nd line drugs used for seizures of eclampsia?

Answer 3

1) MgSO4

2) Benzos (diazepam and lorazepam)

Question 4

MoA for 1st line drug for Simple partial

Answer 4

Carbamazepine. Increases Na channel inactivation

Question 5

Drug for trigeminal neuralgia?

Answer 5

Carbamazepine

Question 6

MoA for 1st line drug for complex partial

Answer 6

Carbamazepine. Increases Na channel inactivation

Question 7

1st line drugs for Tonic-Clonic (3)

Answer 7

Pheytoin, Carbamazeine, Valproic Acid

Question 8

MoA of 1st line drug for status epilepticus prophylaxis?

Answer 8

Pheytonin.

1) Increases Na channel inactivation
2) Inhibition of Glutamate release

Question 9

Parenteral version of phenytoin?

Answer 9

fosphenytoin

Question 10

Carbamazepine - first line drug for? (4)

Answer 10

Simple, Complex, tonic-clonic seizures and tigeminal neuralgia

Question 11

Lamotrigine - MoA? Used for what seizures?

Answer 11

Blocks voltage gates Na channels

Simple, Complex, tonic-clonic seizures

Question 12

Gabapentin - MoA? Used for what seizures?

Answer 12

Inhibits high voltage-activated Ca channels. Simple, Complex, tonic-clonic seizures

Question 13

Gabapentin also used for (other than seizures? (4)

Answer 13

Peripheral neuropath, post-herpetic neuralgia, migranine prophylaxis, bipolar

gaBaPeNtiN (bipolar, migraine Prophyaxis, neuropathy, neuralgia)

Question 14

Topiramate - MoA? Used for what seizures?

Answer 14

1) Blocks voltage gates Na channels
2) Increases GABA
Simple, Complex, tonic-clonic seizures

Question 15

Antiseizure drugs also used for migraine prevention?

Answer 15

Topiramate and Gabapentin

Question 16

Drug used as 2nd line for absence seizures?

Answer 16

Vaproate

Question 17

Valproate MoA? Used for what seizures?

Answer 17

1) increases Na channel inactivation
2) Increases GABA
Simple, Complex, tonic-clonic seizures, absense, and myoclonic

Question 18

Drug used in myoclonic seizures?

Answer 18

Valproate

Question 19

Tigabine - MoA? Used for what seizures?

Answer 19

Inhibits GABA reuptake. Simple and Complex seizures

Question 20

Vigabatrin -MoA? Used for what seizures?

Answer 20

Irreversibly inhibits GABA transaminase, increasing GABA

Used for simple and complex

Question 21

Levetriacetam - MoA? Used for what seizures?

Answer 21

Unknown. Simple, complex, tonic-clonic

Question 22

Antiseizure drugs that cause malaise and fever followed by rapid onset of oral, genital, and ocular purpuric macules

Answer 22

SJS. Lamotrigine, Carbamazepam, Ethosuximide (CLE)

Question 23

Antiseizure Drug that causes SIADH

Answer 23

Carbamazepam

Question 24

Antiseizure Drug that causes agranulocytosis or aplastic anemia?

Answer 24

Carbamazepine

Question 25

Antiseizure Drugs that cause induction of P450s

Answer 25

Carbamazepine, Phenobarbital

Question 26

Ethosuximide side effects?

Answer 26

``` EFGH Ethosuximide Fatigue GI Headache ```

Question 27

Phenytoin - uniqure side effects? (8)

Answer 27

``` PATHS LONGS Phenytoin megaloblastic Anemia (decreases folate absorption) Teratogenesis Hirsutism SLE Lymphadenopathy osteopenia Nystagmus gingival hyperplasia SJS, ```

Question 28

Antiseizure Drug that can cause fatal hepatotoxicity?

Answer 28

Valproic Acid

Question 29

Antiseizure Drug that cause mental dulling, kidney stones and weight loss?

Answer 29

Topiramate

Question 30

Antiseizure drug that is metabolized to phenobarbital?

Answer 30

Primidone

Question 30

Antiseizure drug that also which class of antriarrythmic?

Answer 30

Pheytoin. Class 1B