Epilepsy Flashcards

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1
Q

Q: What is epilepsy?

A

A: A state where part or the entire brain becomes hyperexcitable, losing its inhibitory function.

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2
Q

Q: Is epilepsy a disease?

A

A: No, it is a symptom.

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3
Q

Q: What are common causes of epilepsy?

A

A: Head injury, tumor, infection, vascular disease, and genetic disposition.

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4
Q

Q: What were the two types of seizures in historical classification?

A

A: Grand Mal (“big sickness”) and Petit Mal (“little sickness”).

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5
Q

Q: How are seizures classified today?

A

A: Generalized seizures and partial seizures.

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6
Q

Q: What characterizes generalized seizures?

A

A: Involve the whole brain, often with loss of consciousness, and large synchronous EEG waves.

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7
Q

Q: What are the physical phases of a generalized seizure?

A

Tonic: Stiffening of muscles and jaw clenching.
Clonic: Jerking of limbs and torso.
Atonia: Limpness and regained consciousness.

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8
Q

Q: What characterizes partial seizures?

A

A: Begin in a localized area (focus) and may spread to the entire brain.

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9
Q

Q: What are the three types of partial seizures?

A

Simple Seizures: Focal events with sensory, motor, or psychic symptoms.
Secondary Generalized: Begin at a focus and spread throughout the brain.
Complex Partial: Altered awareness with sensory or motor elements.

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10
Q

Q: What are common symptoms of simple partial seizures based on the brain area involved?

A

Motor cortex: Jerking or twitching.
Occipital lobe: Vivid images or flashing lights.
Temporal lobe: Mood changes.

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11
Q

Q: What are common features of complex partial seizures?

A

A: Altered awareness, déjà vu, jamais vu, and feelings of terror, panic, or ecstasy.

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12
Q

Q: What are absence seizures, and who is most affected?

A

A: Seizures characterized by sudden interruptions in activity, common in children aged 4–14.

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13
Q

Q: What is the characteristic EEG pattern in absence seizures?

A

A: 3 spikes per second.

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14
Q

Q: What determines the neuropsychological impact of epilepsy?

A

A: The seizure locus, type, and length.

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15
Q

Q: How does the age of onset affect cognitive impairments in epilepsy?

A

A: Younger age of onset leads to greater impairments.

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16
Q

Q: What cognitive issues are common in temporal lobe epilepsy?

A

A: Problems with learning, language, and memory.

17
Q

Q: What balance does the brain normally maintain?

A

A: Between excitation (glutamate) and inhibition (GABA).

18
Q

Q: What causes seizures in the brain?

A

A: Excessive synchronous firing of neurons.

19
Q

Q: What brain structure may act as a pacemaker for synchronous activity?

A

A: The thalamus.

20
Q

Q: What drugs are used to treat generalized seizures?

A

A: Phenytoin (Dilantin), barbiturates, and benzodiazepines.

21
Q

Q: How do anticonvulsants like Phenytoin work?

A

A: They enhance GABA’s inhibitory actions and alter neuron firing frequency.

22
Q

Q: How are absence seizures treated?

A

A: With GABA-b antagonists like Zarontin.

23
Q

Q: What is the WADA test, and why is it performed?

A

A: A test that temporarily shuts down one hemisphere to assess memory, language localization, and seizure focus.

24
Q

Q: How can behavioral conditioning prevent seizures?

A

A: By associating an aura with a pleasant stimulus (e.g., jasmine), which interrupts the seizure cycle.