Enzymes Flashcards

1
Q

Enzymes function

A

Catalyse almost all biological functions
Increase rate of reaction

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2
Q

Do enzymes change equilibrium

A

No

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3
Q

What does enzyme catalysis do

A

Lowers activation energy
Forms ES complex

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4
Q

Enzymes increase reaction rate by

A

Lowering activation energy

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5
Q

What factors can help increase reaction rate

A

Substrates in close proximity
In correct orientation
Transition state stabilised

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6
Q

What enzyme is used in RBC

A

Carbonic anhydrase

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7
Q

Ph affects

A

Ionisation state of amino acid r groups

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8
Q

Coenzymes function

A

Help enzymes

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9
Q

NAD is considered a

A

Coenzyme

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10
Q

Where do coenzymes derive from

A

Vitamins

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11
Q

Drugs control inappropriate

A

Enzyme activity

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12
Q

Reversible enzyme inhibitors have a rapid

A

Dissociation

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13
Q

Irreversible enzyme inhibitors have a very slow

A

Dissociation

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14
Q

What inhibitors can be toxic

A

Irreversible

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15
Q

Competitive inhibitors bind to

A

Active site

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16
Q

Competitive inhibitors bind with what for binding

A

Substrate

17
Q

Examples of use of competitive inhibitors

A

Feedback inhibition
Competition treatment for poison ingestion

18
Q

Non competitive inhibitor binds to

A

Allosteric site

19
Q

You cannot overcome inhibition by adding more substrate in what type of inhibitor

A

Non competitive

20
Q

Allosteric enzymes have what type of curve in a graph

A

Sigmodial

21
Q

Features of Allosteric enzymes

A

More than 1 binding site
Changes shape when substrate binds
Co-operative binding
Doesn’t obey MM kinetics