Environmental and Nutritional Disorders Flashcards
Global Disease Burden (GDB)
estimates the burden imposed by environmental disease, including those caused by communicable and nutritional diseases
Disability adjusted life year (DALY)
sum of years of life LOST due to premature mortality and disability in a population
What happened to the GDB from 1990-2010? Cause?
increase in mortality due to HIV/AIDS
What is the leading global cause of health loss?
undernutrition
What is the leading cause of death in developed countries?
ischemic heart disease and cerebral vasculature disease
What are 5 of 10 leading causes of death in developing countries?
Infectious disease
50% of all deaths in kids younger than 5 years are attributed to what 3 diseases?
pneumonia, diarrheal disease, and malaria
What are the categories of emerging infectious diseases?
newly evolved strains or organisms- multi-drug resistant TB
pathogens endemic to other species that recently “jumped” to human population-HIV
pathogens that have been present in human population, but increase in incidence- dengue fever due to warming
What will be the preeminent global cause of environmental disease if no action is taken?
climate change
What will the health impacts of climate change depend on?
extent and rapidity, nature and severity of the consequences, and our ability to mitigate the damage
Affects of heatwaves and air pollution in disease
Cardiovascular, cerebrovascular, and respiratory diseases worsten
Contamination from floods and disruption of clean water supplies causes
Gastroenteritis, cholera, and other food-borne and waterborne infectious diseases
Examples and causes of vector-borne infectious diseases
malaria, Dengue fever; increased temperature, crop failures, and more extreme weather variations
Disrupted crop production causes what?
malnutrition
Toxicology
distribution, effects, and mechanisms of action of toxic agents
How many pounds of toxic chemicals and unrecognized carcinogens are released per year in the US?
4 billion pounds; 72 million lbs carcinogens
Xenobiotics
exogenous chemicals in the environment (air, water, food, soil) that may be absorbed into the body (inhaled, ingested, skin contact)
Lipophilic
can transport and penetrate through the basement membrane; most solvents and drugs
Detoxification
when solvents, drugs, and xenobiotics are metabolized to an inactive water-soluble product
What is the other outcome for solvents, drugs, and xenobiotics besides detox?
activated to form toxic metabolites
Phase 1 reaction of xenobiotics
hydrolysis, reduction, oxidation
Phase 2 reaction of xenobiotics
glucoronidation, sulfation, methylation, and conjugation
Cytochrome P-450
located in ER of the liver, also present in skin, lungs, GI mucosa
catalyzes reactions that either detoxify xenobiotics or convert them into active compounds that cause cell injury
What byproduct can P-450 produce?
ROS–>cell damage