Chapter 7

Question 1

Where do fibroadenomas arise?

Answer 1

Breast

Question 2

Where are leiomyomas most common?

Answer 2

uterus

Question 3

Are angiosarcomas of the liver common?

Answer 3

No

Question 4

What oncogene is commonly activated in Burkitt lymphoma? What translocation?

Answer 4

MYC oncogene

t(8;14)

Question 5

Are sarcomas of the lung common or rare?

Answer 5

Rare

if found, usually a metastasis of another cancer somewhere else

Question 6

p16

Answer 6

produces an inhibitor of cyclin-dependent kinases

stops the cell cycle

Question 7

All pancreatic cancers and 83% of colon cancers have at least one mutational event in what pathway?

Answer 7

TGF-beta

Question 8

Familial adenomatous polyposis

Answer 8

earliest even is los of APC gene function
prevents destruction of beta-catenin–>transcribes genes
APC–>beta-catenin is a component of the WNT signaling pathway

Question 9

Neurofibromatosis type 1

Answer 9

NF1 gene encodes for a GTPase-activing protein that facilitates the conversion of active RAS–>inactive RAS
loss of NF1 keeps RAS active
wild type NF1 gene is a tumor suppressor