Energy Metab

Question 1

TCA cofactors

Answer 1

TLC For Nobody

Thiamine pyrophosphate (TPP)
Lipoic acid
CoA
FAD
NAD+

These cofactors are needed for PDH and a-ketoglutarate

Question 2

Vitamin source of TPP

Answer 2

B1

Question 3

Vitamin source of NAD+

Answer 3

B3

Question 4

Vitamin source of CoA

Answer 4

B5

Question 5

Vitamin source of FAD

Answer 5

B2

Question 6

Garlic breath in patient with vomiting and rice-water stool

Answer 6

arsenic

lipoic acid inhibited by arsenic (lipoic acid required for TCA)

Question 7

Inhibits complex 1

Answer 7

MPP (meperidine synthetic byproduct metabolite)
Amytal
Rotenone

Question 8

Inhibits complex 4

Answer 8

CN
N3- (sodium azide)
CO
H2S

Question 9

Inhibits complex 3

Answer 9

Antimycin A

Question 10

Inhibits ATPase

Answer 10

Oligomycin A

Question 11

TCA process that yields FADH2

Answer 11

Succinate to fumarate

Question 12

FADH2 enters which complex?

Answer 12

complex 2

Question 13

ETC uncoupling agents

Answer 13

Thermogenin
Aspirin
2,4-DNP

(mnemonic TxA2 aka thromboxane A2)

Question 14

Possible products of pyruvate?

Answer 14

oxaloacetate
alanine
lactic acid
acetyl-CoA

Question 15

Major Nitrogen transporters in BLOOD

Answer 15

alanine

glutamine

Question 16

Major regulatory enzymes of TCA cycle

Answer 16

citrate synthase
isocitrate DH
a-ketoglutarate DH

Question 17

RLE of TCA cycle

Answer 17

isocitrate DH