Amino acids Flashcards

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1
Q

Phenylalanine metabolism: Enzyme targeted in Parkinson’s

A

dopa decarboxylase

inhibiting dopa decarcobylase results in inhibiting dopa conversion to dopamine

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2
Q

Enzyme catalyzing conversion of dopa to melanin

A

tyrosinase

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3
Q

Cofactor needed for phenylalanine–>tyrosine

A

BH4

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4
Q

Cofactor needed for tyrosine–> dopa

A

BH4

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5
Q

Cofactor needed for dopamine–>NE

A

vit C

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6
Q

Cofactor needed for dopa–>dopamine

A

vit B6

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7
Q

Cofactor needed for NE–>Epi

A

SAM

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8
Q

Enzyme catalyzing dopa to dopamine

A

dopa decarboxylase

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9
Q

Hormone that facilitates converting NE to epi

A

cortisol

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10
Q

Amino acid required in heme synthesis

A

glycine

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11
Q

PVT TIM HaLL?

A
Phenylalanine
Valine
Threonine
Tryptophan
Isolecuine
Methionine
Histidine
Leucine
Lysine
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12
Q

Basic AA’s

A

Lysine (extra ammonia group)
Arginine (extra ammonia group)
Histidine

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13
Q

Chirality of amino acids found in proteins

A

L-

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14
Q

Acidic AA’s

A

Aspartic acid

Glutamic acid

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15
Q

Amino acids important during periods of growth

A

arginine
histidine

(BASE your build with BASIC amino acids…excluding lysine)

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16
Q

AA’s negatively charged at body pH

A

aspartate

glutamate

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17
Q

AA’s positively charged at body pH

A

arginine

lysine

18
Q

Basic amino acid with NO charge

A

histidine

*the exception
other basic AA’s have positive charge at body pH

19
Q

Amino acids important for nuclear localization signals

A

arginine and lysine

20
Q

Amino acids heavily found in histones

A

arginine
lysine

responsible for POSITIVE charge –> allows easy association with NEGATIVELY charged DNA

21
Q

Arginine required for

A

Creatine
Nitric oxide
Urea

22
Q

AA precursor for Niacin

A

Tryptophan

23
Q

Amino acids requiring B6 in production of their derivatives:

A

tryptophan
histidine
glycine
glutamate

24
Q

AA precursor of porphyrin

A

glycine

heme synthesis

25
Q

B6 is not required to make glutathione from this precursor amino acid:

A

glutamate

26
Q

Histamine requires this cofactor

A

Vit B6

27
Q

GABA precursor

A

Glutamate

28
Q

Cofactors required to make serotonin? What amino acid is serotonin derived from?

A

BH4 and vit B6

tryptophan

29
Q

Glutamate requires vitamin B6 to make

A

GABA

30
Q

AA precursor of melatonin

A

tryptophan

31
Q

ketogenic AAs

A

leucine

lysine

32
Q

glucogenic AAs

A

methionine
valine
histidine

33
Q

glucogenic/ketogenic AAs

A

isoleucine
phenylalanine
threonine
tryptophan

34
Q

Deficiency of phebylalanine hydroxylase

A

PKU

also results from deficiency of BH4

35
Q

Deficiency in tyronase

A

albinism

36
Q

Deficiecny in homogentisate oxidase

A

alkaptonuria

37
Q

Breaks down dopamine into HVA

A

MAO/COMT

38
Q

Required cofactor for PNMT

A

PNMT catalyzes NE to Epi reaction

SAM (S-adenosyl methionine) is required cofactor

39
Q

Precursor to SAM

A

methionine

40
Q

Transfers methyl units to NE to create Epi

A

SAM

41
Q

Transfers methyl units to create phosphocreatine

A

SAM