Amino acids

Question 1

Phenylalanine metabolism: Enzyme targeted in Parkinson’s

Answer 1

dopa decarboxylase

inhibiting dopa decarcobylase results in inhibiting dopa conversion to dopamine

Question 2

Enzyme catalyzing conversion of dopa to melanin

Answer 2

tyrosinase

Question 3

Cofactor needed for phenylalanine–>tyrosine

Answer 3

BH4

Question 4

Cofactor needed for tyrosine–> dopa

Answer 4

BH4

Question 5

Cofactor needed for dopamine–>NE

Answer 5

vit C

Question 6

Cofactor needed for dopa–>dopamine

Answer 6

vit B6

Question 7

Cofactor needed for NE–>Epi

Answer 7

SAM

Question 8

Enzyme catalyzing dopa to dopamine

Answer 8

dopa decarboxylase

Question 9

Hormone that facilitates converting NE to epi

Answer 9

cortisol

Question 10

Amino acid required in heme synthesis

Answer 10

glycine

Question 11

PVT TIM HaLL?

Answer 11

Phenylalanine
Valine
Threonine
Tryptophan
Isolecuine
Methionine
Histidine
Leucine
Lysine

Question 12

Basic AA’s

Answer 12

Lysine (extra ammonia group)
Arginine (extra ammonia group)
Histidine

Question 13

Chirality of amino acids found in proteins

Answer 13

L-

Question 14

Acidic AA’s

Answer 14

Aspartic acid

Glutamic acid

Question 15

Amino acids important during periods of growth

Answer 15

arginine
histidine

(BASE your build with BASIC amino acids…excluding lysine)

Question 16

AA’s negatively charged at body pH

Answer 16

aspartate

glutamate

Question 17

AA’s positively charged at body pH

Answer 17

arginine

lysine

Question 18

Basic amino acid with NO charge

Answer 18

histidine

*the exception
other basic AA’s have positive charge at body pH

Question 19

Amino acids important for nuclear localization signals

Answer 19

arginine and lysine

Question 20

Amino acids heavily found in histones

Answer 20

arginine
lysine

responsible for POSITIVE charge –> allows easy association with NEGATIVELY charged DNA

Question 21

Arginine required for

Answer 21

Creatine
Nitric oxide
Urea

Question 22

AA precursor for Niacin

Answer 22

Tryptophan

Question 23

Amino acids requiring B6 in production of their derivatives:

Answer 23

tryptophan
histidine
glycine
glutamate

Question 24

AA precursor of porphyrin

Answer 24

glycine

heme synthesis

Question 25

B6 is not required to make glutathione from this precursor amino acid:

Answer 25

glutamate

Question 26

Histamine requires this cofactor

Answer 26

Vit B6

Question 27

GABA precursor

Answer 27

Glutamate

Question 28

Cofactors required to make serotonin? What amino acid is serotonin derived from?

Answer 28

BH4 and vit B6 tryptophan

Question 29

Glutamate requires vitamin B6 to make

Answer 29

GABA

Question 30

AA precursor of melatonin

Answer 30

tryptophan

Question 31

ketogenic AAs

Answer 31

leucine | lysine

Question 32

glucogenic AAs

Answer 32

methionine valine histidine

Question 33

glucogenic/ketogenic AAs

Answer 33

isoleucine phenylalanine threonine tryptophan

Question 34

Deficiency of phebylalanine hydroxylase

Answer 34

PKU also results from deficiency of BH4

Question 35

Deficiency in tyronase

Answer 35

albinism

Question 36

Deficiecny in homogentisate oxidase

Answer 36

alkaptonuria

Question 37

Breaks down dopamine into HVA

Answer 37

MAO/COMT

Question 38

Required cofactor for PNMT

Answer 38

PNMT catalyzes NE to Epi reaction SAM (S-adenosyl methionine) is required cofactor

Question 39

Precursor to SAM

Answer 39

methionine

Question 40

Transfers methyl units to NE to create Epi

Answer 40

SAM

Question 41

Transfers methyl units to create phosphocreatine

Answer 41

SAM