Endocytosis (clathrin) Flashcards
After binding, __________ begins to attach to adaptin
Clathrin
When clathrin binds to Adaptin, it forms a ___________
Clathrin basket
__________ coils around the membrane.
Dynamin
What does dynamin use to tighten around the membrane?
GTP
What happens when dynamin brings the membrane completely together?
It causes the vesicles to pop off
Clathrin basket breaks apart using _______ and _______
Auxilin and HSP 70
Auxilin and HSP 70 use _____ to bind to clathrin.
ATP
When the vesicle fuses with the early endosome, what happens?
It drops of the receptor and ligand
After fusing with the early endosome, _____ gets pumped into the early endosome.
Protons
At what pH does the receptor and ligand separate?
At pH 4 or 5
Where does the vesicle of empty receptors go?
To the plasma membrane
Where do the vesicle with ligands go?
To the late endosome
How does the ligand travel to the late endosome?
Through molecular motors
Which molecular motor walls from the positive end to the negative end?
Dynein
Which molecular motors walk on microtubules?
Dynein and kinesin
What shape is clathrin?
It’s a three legged molecule; triskellion
What does the lysosome dump into the late endosome?
Enzymes
When the enzymes are dumped into the late endosome, what happens?
The ligand gets broken down into cholesterol
Microtubules extend from the inner part of the cell which is ___ to the outer part of the cell which is ____
Negative; positive
In step 1 of the clathrin mediated endocytosis __________ binds to a receptor.
Adaptin
