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Clinical Chemistry II > Endocrinology MCQ Part 2 > Flashcards

Endocrinology MCQ Part 2 Flashcards

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1
Q

A patient shows the following data: T4 concentration of 8 ug/dL and T3 uptake of 30%. What is the condition?

A

Euthyroidism

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2
Q

Which secretion is involved in calcium homeostasis?

A

Thyroid hormone

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3
Q

Which is an advantage of T4 assay over PBI (protein bound iodine) test?

A

Prevent contamination of extraneous iodine

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4
Q

Cretinism in infants is caused by

A

hypothyroidism

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5
Q

Which of the parameters are decreased in hypothyroidism?

  1. T4
  2. T3
  3. Resin T3 Uptake
  4. TSH
A

1,2,3,4

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6
Q

Majority of the thyroid hormones in blood are bound with:

A

Thyroxine –binding albumin

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7
Q

Majority of plasma thyroxine ( T4) is:

A

Bound to globulin

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8
Q

Which of these antibodies are associated with auto-immune thyroiditis?
A. Neither microsomal nor thyroglobulin antibodies
B. Microsomalantibodies
C. Thyroglobulinantibodies
D. Both microsomal and thyroglobulin antibodies

A

D.

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9
Q

The gold standard for the assessment of thyroid function is the measurement of

A

TSH

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10
Q

The metabolically active thyroid hormone is

A

T3

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11
Q

The methods for determining thyroid hormones are as follows, EXCEPT:
A. Ash method protein bound iodine
B. Chromatography
C.Radioactive tracer method
D.Colorimetric method

A

B

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12
Q

Increase values of Thyroxine (T4-RIA) is usually associated with the following, EXCEPT:
A. Hyperthyroidism C.Nephrosis
B. Acutethyroiditis D.Graves’disease

A

Nephrosis

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13
Q

The following are thyroid function tests, EXCEPT:
A. Freethyroxine B.FreeTriiodothyronine C.Thyroglobulin D. Testosterone

A

Testosterone

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14
Q

One of the following is NOT associated with hyperthyroidism;
A. Decreased calcium
B. Increased T3
C. Increased PBI
D. Decreased Cholesterol

A

Decreased calcium

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15
Q

Thyroid function tests exclude:

A

ACTH

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16
Q

Hyperthyroidism has been associated with the following, EXCEPT
A. Increased cholesterol
B. Increased T3
C. Increased sugar level
D. Increased T4

A

Increased cholesterol

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17
Q

Assay of T3 & T4 levels, and TSH maybe done by this method, EXCEPT:
A. Spectrophotometer
B. Radioimmunoassay
C. Flame photometer
D. Gamma counter

A

Flame photometer

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18
Q

Hypothyroid test is shown in:

A

Decrease resin T3 & T4

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19
Q

Test for T3 and T4 can be determined by

A

RIA AND EIA TECHNIQUE

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20
Q

Methods for determining T3 and T4 exclude

A

Hemagglutinin

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21
Q

Patient has a TSH result markedly elevated. This maybe due to:

A

Primary hypothyroidism

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22
Q

Determine the free thyroxine index (FT4I) using the given data:
Total T4 = 10 microgram/dL
Resin T3 uptake of patient = 27%
Resin T3 uptake of serum pool = 30%

A

9.0

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23
Q

The use of iodized salt serves to provide iodine for the synthesis of:

A

Thyroid hormone

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24
Q

Normal T3 in serum and normal T4 is interpreted as:

A

Euthyroidism

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25
Q

What is the primary purpose of thyroidal radioiodine uptake test?

A

Differentiate the causes of hyperthyroidism

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26
Q

In hyperthyroidism, resin T3 uptake is:

A

Increase

27
Q

The radioactive count in RT3U test in hypothyroidism is expectedly:

A

Significantly lower

28
Q

The parent compound of steroid hormones is

A

Cholesterol

29
Q

Presence of a very high titer for long acting thyroid stimulator antibodies is highly suggestive of what disorder:

A

Graves disease

30
Q

The major function of thyroid gland is:

A

Production of thyroid hormone

31
Q

In the chemical tests for urinary steroids, the first step is hydrolysis using an
A. enzyme B. acid C. both A & B D. neither A nor B

A

Enzyme and acis

32
Q

The organic reagent used to hydrolyze steroid hormones in the sample is

A

Enzyme

33
Q

The reference method for the assay of steroid hormones is

A

HPLC

34
Q

The method used to quantitate ketogenic steroids is

A

Zimmermann

35
Q

Which adrenal tissue produces secretions which react with DNPH-sulfuric acid?

A

Fascicular cells

36
Q

The major transport protein of cortisol which binds 90% of circulating cortisol is

A

Transcodtin

37
Q

The best time to collect a blood sample for testosterone measurement is

A

8 am

38
Q

The hormones referred to as 18-carbon steroids with unsaturated A ring are

A

Estrogen

39
Q

The major androgen produced in the adrenal cortex is

A

dehydroepiandrosterone

40
Q

In secondary hypocortisolism, plasma ACTH is

A

Decreased

41
Q
  1. The 17-ketosteroids include all of the following except

A. androsterone
B. androstenedione
C. DHEA
D. testosterone

A

Testosterone

42
Q

Dexamethasone suppression test is used to

A

establish the cause of hypercortisolism

43
Q

The following are true regarding the Zimmerman reaction except
A. the reaction requires an acidic medium
B. red-purple product is measured at 520nm
C. dinitrobenzene is the chromogen
D. used to assess androgen production in adrenals

A

Reaction requires an acidic medium

44
Q

The Kober method is performed to

A

assess estrogen production by adrenals

45
Q

Transcortin is able to bind all of the following hormones except

A. cortisol
B. progesterone
C. aldosterone
D. estradiol

A

Estradiol

46
Q

The predominant hormone in the menstrual luteal phase is

A

Progesterone

47
Q

Which hormone-function dyad is incorrect?
A. estrogen stimulates uterine endometrium to proliferate or thicken and negative feedbacking to the pituitary gland
B. FSH–stimulatesmeiosisinovaries;releaseoftheovum C. Progesterone–maintainslevelsofestrogen
D. LH–developmentoftheovumintoacorpusluteum

A

A

48
Q

The predominant estrogen in a gestating woman is

A

Estriol

49
Q

The predominant estrogen in post-menopausal women is

A

Estrone

50
Q

Pituitary secretion of ACTH is inhibited by levels of

A

Cortisol

51
Q

In the Porter-Silber reaction, the 17,21-dihydroxy-20-ketone side chain reacts with

A

Phenylhydrazine

52
Q

The most potent estrogen which is considered the true ovarian hormone is

A

Estradiol

53
Q

All of the following glands secrete steroid hormones except
A. ovaries
B. pituitary gland
C. placenta
D. adrenal cortex

A

Pituitary gland

54
Q

The placenta secretes numerous hormones both protein and steroid. Which of the following hormones is not secreted by the placenta?

A

LH

55
Q

Because of infertility problems, a physician would like to determine when a woman ovulates. The physician orders serial assays of plasma progesterone. From these assays the physician can tell when ovulation occurs because

A

after ovulation, progesterone rapidly increases

56
Q

Which of the following is the major mineralocorticoid?

A

Aldosterone

57
Q

The adrenal medulla secretes which of the following in greatest quantity:

A

Epinephrine

58
Q

In a patient who is suspected of having pheochromocytoma, measurement of which of the following would be most useful?

A

VMA

59
Q

The highest levels of gonadotropins occur

A

atthemidpointofthemenstrualcycle

60
Q

The reference method for the assay of catecholamines is

A

HPLC

61
Q

In a patient who is suspected of overproducing serotonin, the measurement of which of the following would be most useful?

A

5’HIAA

62
Q

In a patient who is suspected of overproducing dopamine, measurement of which of the following would be most useful?

A

HVA

63
Q

In the Zimmerman reaction, the chromogen is

A

Dinitrobenzene

64
Q

The determination of estrogens by the Kober reaction requires which clinical sample?

A

24 hour urine

Clinical Chemistry II (45 decks)

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